1548889-68-4Relevant articles and documents
Optimizing the physicochemical properties of Raf/MEK inhibitors by nitrogen scanning
Aoki, Toshihiro,Hyohdoh, Ikumi,Furuichi, Noriyuki,Ozawa, Sawako,Watanabe, Fumio,Matsushita, Masayuki,Sakaitani, Masahiro,Morikami, Kenji,Takanashi, Kenji,Harada, Naoki,Tomii, Yasushi,Shiraki, Koji,Furumoto, Kentaro,Tabo, Mitsuyasu,Yoshinari, Kiyoshi,Ori, Kazutomo,Aoki, Yuko,Shimma, Nobuo,Iikura, Hitoshi
, p. 309 - 314 (2014/05/06)
Substituting a carbon atom with a nitrogen atom (nitrogen substitution) on an aromatic ring in our leads 11a and 13g by applying nitrogen scanning afforded a set of compounds that improved not only the solubility but also the metabolic stability. The impa