15517-46-1

Basic information

• Product Name: 1,4-phenylenebis((4-hydroxyphenyl)Methanone)
• Synonyms: 1,4-phenylenebis((4-hydroxyphenyl)Methanone)
• CAS NO: 15517-46-1
• Molecular Formula: C₂₀H₁₄O₄
• Molecular Weight: 318.32276
• Mol File: 15517-46-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 318-319 °C
• Boiling Point: 577.6°Cat760mmHg
• Flash Point: 317.1°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 6.12E-14mmHg at 25°C
• Refractive Index: 1.66
• PKA: 7.28±0.15(Predicted)
• CAS DataBase Reference: 1,4-phenylenebis((4-hydroxyphenyl)Methanone)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-phenylenebis((4-hydroxyphenyl)Methanone)(15517-46-1)
• EPA Substance Registry System: 1,4-phenylenebis((4-hydroxyphenyl)Methanone)(15517-46-1)

Safety Data

• Hazardous Substances Data: 15517-46-1(Hazardous Substances Data)

Usage

Preparation

Obtained by Fries rearrangement of phenyl terephtha-–late (diester) with aluminium chloride at 185–195° for 25 min.

InChI:InChI=1/C20H14O4/c21-17-9-5-15(6-10-17)19(23)13-1-2-14(4-3-13)20(24)16-7-11-18(22)12-8-16/h1-12,21-22H

Upstream product

• 100-66-3 methoxybenzene 
• 100-20-9 terephthaloyl chloride 
• 15517-45-0 1,4-phenylenebis[(4-methoxypheny)lmethanone] 
• 935-14-8 1,4-diethynylbenzene 
• 108-95-2 phenol 
• 1539-04-4 diphenyl terephthalate 

Downstream Products

• 150940-37-7 1,4-bis-(4-acetoxy-benzoyl)-benzene 
• 6315-88-4 1,4-bis-[4-(3-bromo-benzoyloxy)-benzoyl]-benzene 

Relevant articles and documents

1. 4 - b (4 - hydroxybenzene acyl) rectifying section polyetherketoneetherketoneketone copolymer preparation method

The invention relates to a 1,4-dis(4-hydroxyl pyrazolyl)benzene and a preparation method of a polyetheretherketone copolymer, which belongs to the high-molecular material field. The method comprises the following steps: selecting nitrobenzene and tetrachloroethanes as solvents, taking aluminium trichloride as a catalyst for a Fries rearrangement reaction to obtain a 1,4-dis(4-hydroxyl pyrazolyl)benzene monomer, then adding 4,4'-difluorobenzophenone and sulfobenzide in a reaction container equipped with a thermometer, protecting under nitrogen, heating to 160-180 DEG C and adding carbonate, heating to 165-190 DEG C and adding a bisphenol monomer, wherein the bisphenol monomer is a mixture of hydroquinone and 1,4-dis(4-hydroxyl pyrazolyl)benzene, performing a program temperature control reaction to obtain a polymer, and processing to obtain the refined polyetheretherketone random polymer.

Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C C Triple Bond Cleavage

Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.