156329-62-3

Basic information

• Product Name: Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI)
• Synonyms: Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI);Methyl 3-cyanobicyclo[1.1.1]pentane-1-carboxylate;Methyl 3-Cyanobicyclo[1.1.1]Pentane-1-Carboxylate(WX120558);methyl 1-cyanobicyclo[1.1.1]pentane-3-carboxylate
• CAS NO: 156329-62-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Product Categories: CARBOXYLICESTER
• Mol File: 156329-62-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI)(156329-62-3)
• EPA Substance Registry System: Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI)(156329-62-3)

Safety Data

• Hazardous Substances Data: 156329-62-3(Hazardous Substances Data)

Usage

General Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI) is a chemical compound with a bicyclic structure and a carboxylic acid functional group. It also contains a cyano group and is in the form of a methyl ester. Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-cyano-, methyl ester (9CI) has potential applications in various industries, including pharmaceuticals, agrochemicals, and materials. It may be used as a building block for the synthesis of other compounds, or as a reagent in organic chemistry reactions. Its unique structure and functional groups make it an interesting target for chemical synthesis and research. However, like all chemical compounds, it should be handled with care and in accordance with safety guidelines.

Upstream product

• 115913-30-9 1,1′-(bicyclo[1.1.1]pentane-1,3-diyl)bis(ethan-1-one) 
• 156329-77-0 methyl 3-carbamoylbicyclo<1.1.1>pentane-1-carboxylate 
• 115913-32-1 dimethyl bicyclo<1.1.1>pentane-1,3-dicarboxylate 
• 115913-31-0 1,3-bis(chlorocarbonyl)bicyclo<1.1.1>pentane 
• 110371-22-7 methyl 3-(chlorocarbonyl)bicyclo<1.1.1>pentane-1-carboxylate 
• 83249-10-9 3‐(methoxycarbonyl)bicyclo[1.1.1]pentane‐1‐carboxylic acid 
• 56842-95-6 bicyclo<1.1.1>pentane-1,3-dicarboxylic acid 

Downstream Products

• 83249-02-9 3-cyanobicyclo<1.1.1>pentane-1-carboxylic acid 
• 1370705-38-6 (R)-2-{N-{[3-(1,2,4-oxadiazol-3-yl)bicyclo[1.1.1]pentan-1-yl]-methyl}-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide 
• 1370705-40-0 (R)-2-{4-chloro-N-[(3-cyanobicyclo[1.1.1]pentan-1-yl)methyl]phenylsulfonamide}-5,5,5-trifluoropentanamide 
• 1370705-39-7 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carbonitrile 
• 156329-61-2 3-bromobicyclo<1.1.1>pentane-1-carbonitrile 

Relevant articles and documents

Quinuclidine derivative, method for preparing same and application of quinuclidine derivative

The invention relates to a quinuclidine derivative, a pharmaceutically acceptable salt, pro-drug and solvent compound of the quinuclidine derivative, a method for preparing the quinuclidine derivative, a drug composition with the quinuclidine derivative and the pharmaceutically acceptable salt, pro-drug and solvent compound and pharmaceutical application of the quinuclidine derivative. The quinuclidine derivative, the pharmaceutically acceptable salt, pro-drug and solvent compound, the method, the drug composition and the pharmaceutical application have the advantage that the compound is excellent in M3 receptor antagonist activity and accordingly can be used as a novel efficient drug for chronic obstructive pulmonary diseases.

Synthesis and biological evaluation of 2-(3′-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist

The design and synthesis of 2-(3′-(1H-tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGluR1 antagonist is reported. S-TBPG is characterized by the bioisosteric replacement of the distal carboxy group of 2-(3′-carboxybicyclo[1.1.1]pent-1-yl)glycine (S-CBPG) by a tetrazolyl moiety. Despite a moderate reduction in potency, S-TBPG is a selective mGluR1 antagonist (69 μM), with no activity at other mGluR subtypes. The interesting biological profile of S-TBPG, coupled with its peculiar chemical structure, is discussed in terms of the structure-activity relationship (SAR) of mGluR1 antagonists.