156387-05-2Relevant articles and documents
SYNTHESIS OF 2-SILATETRALIN DERIVATIVES BEARING OXYGEN FUNCTIONAL GROUPS
Hoshino, Osamu,Hirokawa, Akihisa,Taguchi, Toru,Miyauchi, Kenji
, p. 883 - 896 (2007/10/02)
The Grignard reagents of methoxy- or methylenedioxyphenylmethyl chlorides (12a-e) were treated with trichlorovinylsilane in THF or ether to give methoxy- or methylenedioxybenzyldichlorovinylsilanes (13a-e).The reaction of 13a-d in the presence of AlCl3 in CS2 or CH2Cl2 followed by treatment with MeOH and cyclohexylamine or Et3N afforded methoxy-2-silatetralins (16a-d).Treatment of 16a-d with MeMgI or EtMgBr in ether gave the corresponding 2,2-dimethyl- or 2,2-diethyl-2-silatetralins (17a-d or 18).Demethylation of 17a, 17b or 18 with BBr3 in CH2Cl2 furnished hydroxy-2-silatetralins (19a, 19b or 20).