157047-96-6 Usage
Description
Benzomalvin A is a fungal metabolite derived from Penicillium, which exhibits a range of biological activities, including the inhibition of yeast α-glucosidase, modulation of plasma glucose levels, and antagonism of neurokinin-1 (NK1) receptors.
Uses
Used in Pharmaceutical Industry:
Benzomalvin A is used as a potential therapeutic agent for diabetes management due to its ability to inhibit yeast α-glucosidase and decrease plasma glucose levels in vivo. This property makes it a promising candidate for the development of novel treatments for hyperglycemia and related metabolic disorders.
Used in Neurological Applications:
Benzomalvin A is used as a neurokinin-1 (NK1) receptor antagonist, which can inhibit the binding of substance P in various species, including guinea pigs, rats, and humans. This characteristic suggests its potential use in the treatment of neurological disorders and conditions where the NK1 receptor plays a significant role, such as migraine, anxiety, and depression.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, given the diverse applications of benzomalvin A, it is plausible that novel drug delivery systems could be developed to enhance its bioavailability, targeting, and therapeutic outcomes in various medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 157047-96-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,0,4 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 157047-96:
(8*1)+(7*5)+(6*7)+(5*0)+(4*4)+(3*7)+(2*9)+(1*6)=146
146 % 10 = 6
So 157047-96-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H19N3O2/c1-26-21(15-16-9-3-2-4-10-16)22-25-19-13-7-5-11-17(19)24(29)27(22)20-14-8-6-12-18(20)23(26)28/h2-14,21H,15H2,1H3
157047-96-6Relevant articles and documents
The first total synthesis of (-)-benzomalvin A via intramolecular Aza-Wittig reactions
Sugimori, Toshiyuki,Okawa, Tomohiro,Eguchi, Shoji,Yashima, Eiji,Okamoto, Yoshio
, p. 869 - 870 (1997)
The first total synthesis of (-)-benzomalvin A 1, which possesses quinazolin-4(3H)-one moiety and 1,4-benzodiazepin-5-one moiety, was described. Both of 6- and 7-membered ring skeletons were efficiently constructed by intramolecular aza-Wittig reactions as the key reactions.
