15707-32-1

Basic information

• Product Name: 2-Chloro-3-methoxy-1,4-naphthoquinone
• Synonyms: 2-Chloro-3-methoxy-1,4-naphthoquinone
• CAS NO: 15707-32-1
• Molecular Formula: C₁₁H₇ClO₃
• Molecular Weight: 222.62
• Mol File: 15707-32-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 368.8°C at 760 mmHg
• Flash Point: 164.8°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 2-Chloro-3-methoxy-1,4-naphthoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-methoxy-1,4-naphthoquinone(15707-32-1)
• EPA Substance Registry System: 2-Chloro-3-methoxy-1,4-naphthoquinone(15707-32-1)

Safety Data

• Hazardous Substances Data: 15707-32-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H7ClO3/c1-15-11-8(12)9(13)6-4-2-3-5-7(6)10(11)14/h2-5H,1H3

Upstream product

• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 18398-36-2 3,4-dichloro-[1,2]naphthoquinone 

Downstream Products

• 15252-69-4 2-chloro-1,4-dihydro-3-methylamino-1,4-dioxonaphthalene 
• 69009-67-2 2-methoxy-3-(phenylamino)naphthalene-1,4-dione 
• 6956-96-3 2,3-dimethoxy-1,4-naphthoquinone 
• 134717-18-3 2-Methoxy-3-phenylselanyl-[1,4]naphthoquinone 
• 76309-69-8 2-(cyclohexylthio)-3-hydroxy-1,4-naphthoquinone 

Relevant articles and documents

Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human fibroblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3-89.5 μM, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety.