157162-16-8

Basic information

• Product Name: METHYL 3-HYDROXY-5-TRIFLUOROMETHYLTHIOPHENE-2-CARBOXYLATE
• Synonyms: 3-HYDROXY-5-(TRIFLUOROMETHYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;METHYL 3-HYDROXY-5-TRIFLUOROMETHYLTHIOPHENE-2-CARBOXYLATE;2-THIOPHENECARBOXYLIC ACID, 3-HYDROXY-5-(TRIFLUOROMETHYL)-, METHYL ESTER;2-Thiophenecarboxylic acid, 3-hydroxy-5-(trifluoromethyl)-, meth
• CAS NO: 157162-16-8
• Molecular Formula: C7H5F3O3S
• Molecular Weight: 226.17
• Mol File: 157162-16-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 62°C/3mm
• Appearance: /
• Density: 1.52g/ml
• PKA: 8.47±0.15(Predicted)
• CAS DataBase Reference: METHYL 3-HYDROXY-5-TRIFLUOROMETHYLTHIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-HYDROXY-5-TRIFLUOROMETHYLTHIOPHENE-2-CARBOXYLATE(157162-16-8)
• EPA Substance Registry System: METHYL 3-HYDROXY-5-TRIFLUOROMETHYLTHIOPHENE-2-CARBOXYLATE(157162-16-8)

Safety Data

• Hazardous Substances Data: 157162-16-8(Hazardous Substances Data)

Usage

General Description

Methyl 3-hydroxy-5-trifluoromethylthiophene-2-carboxylate is a chemical compound with the molecular formula C8H5F3O3S. It is a derivative of thiophene, which is a five-membered heterocyclic compound containing sulfur. The presence of a hydroxy and a carboxylic ester group in the compound suggests its potential use in pharmaceutical and medicinal chemistry. The trifluoromethyl group can affect the physicochemical properties and reactivity of the compound, making it valuable for various applications in organic synthesis and drug discovery. This chemical compound has the potential to be used in the development of new drugs and agrochemicals due to its unique structure and functional groups.

Upstream product

• 2365-48-2 Methyl thioglycolate 
• 144850-59-9 ethyl 3-bromo-3,4,4,4-tetrafluorobutanoate 
• 26717-84-0 3-methoxy-4,4,4-trifluoro-2-butenoic acid ethyl ester 

Downstream Products

• 933472-39-0 3-ethoxy-5-trifluoromethyl-thiophene-2-carboxylic acid methyl ester 
• 217959-45-0 4-Hydroxy-2-(trifluoromethyl)thiophene 
• 217959-85-8 3-Hydroxy-5-trifluoromethyl-2-thiophenecarboxylic Acid 

Relevant articles and documents

Preparation of 4-hydroxy-2-trifluoromethylthiophene: A novel bioisostere of α,α,α-trifluoro-m-cresol

A simple and convenient four-step synthesis of 4-hydroxy-2- trifluoromethylthiophene (1) a novel bioisostere of α,α,α- trifluoro-m-cresol is reported. The key step is the condensation between ethyl 3-methoxy-4,4,4-trifluorocrotonate and methyl thioglycolate to form methyl 3-hydroxy-5- trifluoromethylthiophene-2-carboxylate (6). Hydrolysis of the ester followed by decarboxylation furnishes 1. Multi-hundred gram quantities of 1 have been obtained utilizing the present procedure.

Thienyloxypyridines and-pyrimidines useful as herbicidal agents

The present invention provides a herbicidal compound of formula I, methods for the preparation thereof and intermediates useful therefor. wherein X and Y are each independently O or S; Z is N or CR4.

Herbicidal 2-(cycloalk(en)yloxy)-6-(hetero)aryloxy(thio)pyridines

The novel compounds of formula I: wherein R, A, X1, X2, X3and Z have the meaning given in claim 1, and the agronomically acceptable salts or N-oxide thereof, and herbicidal compositions containing such compounds as active ingredients.