Harmful:;15718-46-4Relevant articles and documents
Multifunctional core-shell Pd@Cu on MoS2 as a visible light-harvesting photocatalyst for synthesis of disulfide by S[sbnd]S coupling
Yusuf, Mohammad,Song, Sehwan,Park, Sungkyun,Park, Kang Hyun
, (2021/02/21)
Visible light harvesting materials are considered promising cost-effective heterogenous catalysts for organic synthesis. A novel and efficient synthesis of multifunctional core-shell Pd@Cu/MoS2 nanostructures is utilized for synthesis of disulfides by S[sbnd]S Coupling. The Pd@Cu core-shell was obtained by one-pot hydrothermal synthesis, and a simple method was used to load it onto the MoS2. The as-prepared materials were characterized by scanning electron microscopy, transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, UV–vis diffuse reflectance spectroscopy, and photoluminescence spectroscopy. The Pd@Cu/MoS2 nanostructures revealed excellent photocatalytic activity, reusability, and stability towards the oxidative coupling of mercaptans to disulfanes. The outstanding photocatalytic activity of Pd@Cu/MoS2 will enhance interest in the field of multifunctional core-shell nanomaterials as photocatalysts for a wide variety of applications.
Biocatalytic synthesis of diaryl disulphides and their bio-evaluation as potent inhibitors of drug-resistant Staphylococcus aureus
Saima,Soni, Isha,Lavekar, Aditya G.,Shukla, Manjulika,Equbal, Danish,Sinha, Arun K.,Chopra, Sidharth
, p. 171 - 178 (2019/01/04)
Staphylococcus aureus is a WHO Priority II pathogen for its capability to cause acute to chronic infections and to resist antibiotics, thus severely impacting healthcare systems worldwide. In this context, it is urgently desired to discover novel molecules to thwart the continuing emergence of antimicrobial resistance. Disulphide containing small molecules has gained prominence as antibacterials. As their conventional synthesis requires tedious synthetic procedure and sometimes toxic reagents, a green and environmentally benign protocol for their synthesis has been developed through which a series of molecules were obtained and evaluated for antibacterial activity against ESKAPE pathogen panel. The hit compound was tested for cytotoxicity against Vero cells to determine its selectivity index and time-kill kinetics was determined. The activity of hit was determined against a panel of S. aureus multi-drug resistant clinical isolates. Also, its ability to synergize with FDA approved drugs was tested as was its ability to reduce biofilm. We identified bis(2-bromophenyl) disulphide (2t) as possessing equipotent antimicrobial activity against S. aureus including MRSA and VRSA strains. Further, 2t exhibited a selectivity index of 25 with concentration-dependent bactericidal activity, synergized with all drugs tested and significantly reduced preformed biofilm. Taken together, 2t exhibits all properties to be positioned as novel scaffold for anti-staphylococcal therapy.
Three monomeric compounds containing the dipyrimidine-2-thiolategold(I) anion
Neils, Thomas L.,Biros, Shannon M.,Staples, Richard J.,Wackerle, Brandon G.,Harrison, Robert B.
, p. 474 - 478 (2018/11/06)
Three complexes containing the dipyrimidine-2-thiolategold(I) anion, [Au(2-pymS)2]-, (2-pymSH = pyrimidine-2-thione), Na[Au(2-pymS)2] (1), N(C2H5)4[Au(2-pymS)2] (2), and H[Au(2-pymS)2] (3), have been synthesized and characterized by spectroscopy (1H NMR, IR, and ESI –MS) and by X-ray crystallography. The monomeric compounds are easily solubilized in water and in various polar organic solvents. The complex anion shows a linear S–Au–S geometry in all three compounds, but the counter cations create a different space group for each compound and also deter Au–Au interactions.
