15723-90-7

Basic information

• Product Name: 4-NITROBENZAMIDINE, HYDROCHLORIDE
• Synonyms: p-nitro-benzamidinmonohydrochloride;4-NITROBENZAMIDINE, HYDROCHLORIDE;4-Nitrobenzamidine,HCl;4-Nitrobenzimidamide, HCl;4-Nitrobenzenecarboximidamide hydrochloride, 4-Nitrobenzimidamide hydrochloride;4-Nitrobenzamidine hydrochloride ,97%;Benzamidine, p-nitro-, hydrochloride (6ci);Benzamidine, p-nitro-, monohydrochloride
• CAS NO: 15723-90-7
• Molecular Formula: C₇H₇N₃O₂*ClH
• Molecular Weight: 201.61
• EINECS: 239-817-4
• Product Categories: blocks;Carboxes;NitroCompounds;Aromatics Compounds;Aromatics
• Mol File: 15723-90-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 286-288°C
• Boiling Point: 310.6 °C at 760 mmHg
• Flash Point: 141.6 °C
• Appearance: Pale yellow crystalline solid
• Vapor Pressure: 0.000596mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Methanol, Warm Water
• CAS DataBase Reference: 4-NITROBENZAMIDINE, HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROBENZAMIDINE, HYDROCHLORIDE(15723-90-7)
• EPA Substance Registry System: 4-NITROBENZAMIDINE, HYDROCHLORIDE(15723-90-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36/37
• RTECS: CV6296000
• Hazardous Substances Data: 15723-90-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Crystalline Solid

Uses

Different sources of media describe the Uses of 15723-90-7 differently. You can refer to the following data:
1. 4-Nitrobenzamidine Hydrochloride is used in the preparation of labelled Diminazene (D479550).
2. 4-Nitrobenzamidine, Hydrochloride (cas# 15723-90-7) is a compound useful in organic synthesis.

InChI:InChI=1/C7H7N3O2.ClH/c8-7(9)5-1-3-6(4-2-5)10(11)12;/h1-4H,(H3,8,9);1H

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 52708-02-8 4-nitrobenzimidic acid methyl ester 
• 40546-45-0 ethyl 4-nitrobenzenecarboximidoate hydrochloride 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 3858-83-1 p-aminobenzamidine 
• 91272-20-7 2-(p-nitrophenyl)-5,6-pentamethylenepyrimidin-4(3H)-one 
• 2498-50-2 4-aminobenzamidine monohydrochloride 
• 1106994-63-1 C₂₂H₁₄N₄O₄ 
• 95222-73-4 2,4-bis-(4-nitro-phenyl)-6-phenyl-pyrimidine 
• 1638156-57-6 4-ethynyl-5-(4-methylphenyl)-2-(4-nitrophenyl)pyrimidine 
• 83217-23-6 4,6-dichloro-2-(4-nitrophenyl)pyrimidine 
• 83217-40-7 4-(4,6-dichloropyrimidin-2-yl)aniline 
• 176100-76-8 2-(4-nitrophenyl)pyrimidine-4,6-diol 
• 69570-93-0 5‐methyl‐2‐(4‐nitrophenyl)‐1H‐benzo[d]imidazole 
• 729-13-5 2-(4-nitrophenyl)benzimidazole 

Relevant articles and documents

Synthesis and biophysical testing of a novel pyrrole-containing polyamide-benzamidine hybrid

This communication details the rationale for the design of a novel polyamide molecule, 1, in which the standard dimethylamino C-terminus functionality has been replaced with a benzamidine moiety. The synthesis of this molecule and the subsequent DNA binding properties, determined from surface plasmon resonance and DNA melts are reported. The benzamidine moiety was shown to significantly increase the binding affinity of the polyamide to its cognate AATTT sequence compared to the parent C-terminus compound 2.

Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors

BTK is an effective target for the treatment of B-cell malignant tumors and autoimmune diseases. In this work, a series of 2-phenyl pyrimidine derivatives were prepared and their preliminary in vitro activities on B-cell leukemia cells as well as the BTK enzyme were determined. The results showed that compound 11g displayed the best inhibitory activity on BTK with an inhibition rate of 82.76% at 100 nM and excellent anti-proliferation activity on three B-cell leukemia lines (IC50 = 3.66 μM, 6.98 μM, and 5.39 μM against HL60, Raji and Ramos, respectively). Besides, the flow cytometry analysis results indicated that 11g inhibited the proliferation of the Raji cells in a dose- and time-dependent manner, and blocked the Ramos cells at the G0/G1 phase, which is in accordance with the positive control ibrutinib. The mechanism investigation demonstrated that 11g could inhibit the phosphorylation of BTK and its downstream substrate phospholipase γ2 (PLCγ2). All these results showed that 11g was a promising lead compound that merited further optimization as a novel class of BTK inhibitor for the treatment of B-cell lymphoblastic leukemia.

Bispyrimidine diamine and preparation method thereof

The invention discloses bispyrimidine diamine and a preparation method thereof. According to the preparation method, the bispyrimidine diamine is prepared through a five-step reaction by taking nitrobenzonitrile as a raw material. The bispyrimidine diamine disclosed by the invention can also be used as a raw material for synthesising high-performance polymers, such as polyimide and polyamide, and has a wide application prospect in the aspect of high-performance fibres.

Synthesis and structure of aroylamidines and N-arylbenzamidines hydrochlorides

Aroylamidines can be obtained as salts in a reaction of the corresponding arylcarbonitriles with anhydrous ethanol in the presence of dry HCl followed by treating intermediate imidoesters with alcoholic solution of ammonia. N-Arylbenzamidines are obtained by reacting benzonitrile with arylamines in the presence of AlCl3. The structure of arylamines and the reaction conditions signifi cantly affect the yield of the target product, and sometimes the very possibility of its preparation. Pleiades Publishing, Ltd., 2012.