1572439-33-8

Basic information

• Product Name: 4-((4-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-2-yl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide
• Synonyms: 4-((4-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-2-yl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide
• CAS NO: 1572439-33-8
• Molecular Weight: 490.545
• Mol File: 1572439-33-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((4-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-2-yl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-2-yl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide(1572439-33-8)
• EPA Substance Registry System: 4-((4-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-2-yl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide(1572439-33-8)

Safety Data

• Hazardous Substances Data: 1572439-33-8(Hazardous Substances Data)

Upstream product

• 444731-72-0 2,3-dimethyl-6-amino-2H-indazole 
• 444731-74-2 N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine 
• 723-46-6 sulfamethoxazole 

Relevant articles and documents

Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents

A novel series of pazopanib derivatives were designed, synthesized, and evaluated for their inhibitory activity against a series of kinases including VEGFR-2, EGFR, AKT1, ALK1, and ABL1. The anti-angiogenic activities ex vivo of some compounds were also investigated. Compounds P2d and P2e demonstrated outstanding inhibitory activity against VEGFR-2 and ABL1 and higher anti-angiogenic activity compared with Pazopanib, the reference standard. These two compounds (P2d and P2e) could be used as novel lead compounds for further development of anticancer agents.