1576-70-1 Usage
General Description
1-Methoxy-10H-phenothiazine, also known as methoxypsoralene, is a chemical compound belonging to the phenothiazine family. It is a yellow crystalline powder with a molecular formula of C13H11NOS and a molecular weight of 229.3 g/mol. 1-Methoxy-10H-phenothiazine is used as a photosensitizing agent in the treatment of skin disorders such as psoriasis and vitiligo. When exposed to ultraviolet A (UVA) light, 1-Methoxy-10H-phenothiazine becomes activated and forms crosslinks with DNA, which inhibits cell division and leads to the death of rapidly dividing cells. This mechanism of action makes it useful in the treatment of skin conditions characterized by excessive cell turnover. Additionally, it is also being studied for its potential anti-cancer properties and its ability to cross the blood-brain barrier, making it a potential candidate for neurological therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1576-70-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,7 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1576-70:
(6*1)+(5*5)+(4*7)+(3*6)+(2*7)+(1*0)=91
91 % 10 = 1
So 1576-70-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H11NOS/c1-15-10-6-4-8-12-13(10)14-9-5-2-3-7-11(9)16-12/h2-8,14H,1H3
1576-70-1Relevant articles and documents
Antioxidant activities of phenothiazines and related compounds: Correlation between the antioxidant activities and dissociation energies of O-H or N-H bonds
Yamamura, Tatsuo,Suzuki, Kyouichi,Yamaguchi, Tatsuya,Nishiyama, Tomihiro
, p. 413 - 419 (2007/10/03)
The antioxidant activities of phenothiazines, carbazoles, and related diphenylamines were evaluated in the oxidation of tetralin at 60°C and linoleic acid micelles in aqueous dispersion at 37°C induced by an azo initiator. Phenothiazines were highly antioxidant in both systems. Although diphenylamine and carbazole were not good antioxidants, those having a hydroxy group as a substituent at the ortho or para position to the amino group were potently antioxidant. The antioxidant activity of o-hydroxydiphenylamine was much greater than that of other compounds in both systems due to a stabilization of the phenoxyl radical by delocalization of the unpaired electron to the p-type lone pair of the amino group. A semiempirical MNDO-AM1 calculation was applied to study hydrogen abstractions of antioxidants in the chain process of autoxidation. These results indicated that the rates of oxidation during the induction period correlated with the dissociation energies of the O-H or N-H bonds.