157652-31-8 Usage
Description
3,4-Difluoro-2-methylbenzoic acid is an organic compound characterized by its unique molecular structure featuring two fluorine atoms at the 3rd and 4th positions, and a methyl group at the 2nd position on a benzoic acid backbone. 3,4-DIFLUORO-2-METHYLBENZOIC ACID is known for its versatile chemical properties and wide range of applications across different industries.
Uses
Used in Organic Synthesis:
3,4-Difluoro-2-methylbenzoic acid is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for selective functionalization and modification, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,4-difluoro-2-methylbenzoic acid serves as an essential raw material for the development of new drugs. Its chemical properties enable the creation of novel drug candidates with potential therapeutic applications.
Used in Agrochemicals:
3,4-Difluoro-2-methylbenzoic acid is utilized in the agrochemical industry for the synthesis of various pesticides and other agricultural chemicals. Its incorporation into these products can enhance their efficacy and selectivity, leading to improved crop protection and yield.
Used in Dye Industry:
In the dye industry, 3,4-difluoro-2-methylbenzoic acid is employed as a starting material for the production of various dyes and pigments. Its unique chemical structure contributes to the development of dyes with specific color properties and improved performance characteristics.
Used in Medicine Field:
3,4-Difluoro-2-methylbenzoic acid finds application in the medical field, where it is used in the development of diagnostic tools and therapeutic agents. Its chemical properties make it a promising candidate for the creation of novel medical products.
Used in Electronic Industry:
In the electronic industry, 3,4-difluoro-2-methylbenzoic acid is used in the development of advanced materials for electronic devices. Its unique properties can contribute to the creation of materials with improved electrical and thermal performance, enhancing the efficiency and reliability of electronic components.
Used in Polymer Material:
3,4-Difluoro-2-methylbenzoic acid is also utilized in the polymer material industry, where it is used to develop new polymers with specific properties. Its incorporation into polymer formulations can lead to materials with enhanced mechanical, thermal, and chemical resistance, making them suitable for a wide range of applications.
Check Digit Verification of cas no
The CAS Registry Mumber 157652-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,6,5 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 157652-31:
(8*1)+(7*5)+(6*7)+(5*6)+(4*5)+(3*2)+(2*3)+(1*1)=148
148 % 10 = 8
So 157652-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O2/c1-4-5(8(11)12)2-3-6(9)7(4)10/h2-3H,1H3,(H,11,12)
157652-31-8Relevant articles and documents
Synthetic method 3-4 -difluoro -2 - methylbenzoic acid and intermediate thereof
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Paragraph 0061-0065, (2021/08/25)
The invention relates to a preparation method of 3-4 -difluoro -2 -methylbenzoic acid and an intermediate thereof, belonging to the field of medicinal chemistry. The intermediate of 3, 4 - difluoro -2 - methylbenzoic acid is prepared by reacting a compound of formula (A) with a Lewis acid in carbon tetrachloride and then treating to obtain a compound of formula (B), wherein, R. 1 Be selected from chlorine. Bromine, iodine, the reactants of the reaction do not contain elementary halogen. The preparation method of 3-4 -difluoro -2 -methylbenzoic acid comprises the following steps: (B) subjecting the compound to hydrolysis reaction in water in the presence of an acid or a base, and then treating to obtain a compound of formula (C) wherein R. 1 Selected from chlorine, bromine, iodine. The invention provides a technical scheme for synthesizing 3 and 4 -difluoro -2 - methylbenzoic acid. The utility model avoids the use of toxic and harmful elementary halogen elements and Grignard reagents, and is safe and environment-friendly. Reaction conditions are mild, equipment requirements are not high, and industrial amplification production is facilitated.
Preparation method of baloxavir intermediate
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Paragraph 0089-0094, (2020/03/17)
The invention relates to a preparation method of a baloxavir intermediate and belongs to the field of medicinal chemistry. With the compound (A) as an initial raw material, the method includes a halogenation reaction, a Grignard reaction, a halogenation r
Method for preparing baloxavir intermediate and intermediate obtained by method
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Paragraph 0042; 0046; 0047; 0048, (2020/12/30)
The invention belongs to the technical field of chemical synthesis, and provides a method for preparing a balosavir intermediate. The method comprises the following steps: (1) methylating 3,4-difluorobromobenzene to obtain a compound A-1; (2) reacting the compound A-1 with a Grignard reagent, then introducing carbon dioxide gas for reaction, and adding acid for acidification to obtain a compound A-2; (3) brominating the compound A-2 to obtain a compound A-3; (4) adding diphenyl disulfide and a reducing agent 1 into THF, dropwise adding methanol, dropwise adding the compound A-3, and reacting to obtain a compound A-4; (5) carrying out ring closing reaction on the compound A-4 in polyphosphoric acid to obtain a compound A-5; and (6) reducing the compound A-5 into alcohol by adopting a reducing agent 2 to obtain a compound A-6. According to the method, highly toxic and foul thiophenol is prevented from being used while expensive reagents are prevented from being used, so that the processcost is reduced. The invention also provides an intermediate compound prepared by the method.
