157921-26-1

Basic information

• Product Name: 4'-Nitro-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide
• CAS NO: 157921-26-1
• Molecular Weight: 491.546
• Mol File: 157921-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-Nitro-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Nitro-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide(157921-26-1)
• EPA Substance Registry System: 4'-Nitro-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide(157921-26-1)

Safety Data

• Hazardous Substances Data: 157921-26-1(Hazardous Substances Data)

Upstream product

• 18211-41-1 4'-nitro-[1,1'-biphenyl]-2-carboxylic acid 
• 27370-39-4 4'-nitro-biphenyl-2-carbonyl chloride 
• 137973-03-6 6-<(4-aminophenyl)carbonyl>-2,6-diazabicyclo<5.4.0>undeca-1(7),8,10-trien-3-one 

Downstream Products

• 157921-35-2 4'-Amino-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide 

Relevant articles and documents

Nonpeptide arginine vasopressin antagonists for both V(1A) and V2 receptors: Synthesis and pharmacological properties of 2-Phenyl-4'- [(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide derivatives

A series of compounds structurally related to 4'-[(2,3,4,5-tetrahydro- 1H-1-benzazepin-1-yl)carbonyl]benzanilide was synthesized and demonstrated to have arginine vasopressin (AVP) antagonist activity for both V(1A) and V2 receptors. The introduction of a phenyl or a 4-substituted phenyl group into the ortho position of the benzoyl moiety resulted in an increase in both binding affinity and antagonistic activity. The 2-(4-methylphenyl) derivative (1g) exhibited high antagonistic activities for both V(1A) (8.6- fold) and V2 (38-fold) receptors and high oral activity (8.6-fold) compared with the 2-methyl lead compound (1a). Detail of the synthesis and the pharmacological properties of this series are presented.