1580504-38-6

Basic information

• Product Name: 2-(4-(6-methoxy-4-methylpyridin-3-yl)benzyloxy)nicotinamide
• CAS NO: 1580504-38-6
• Molecular Weight: 349.389
• Mol File: 1580504-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(6-methoxy-4-methylpyridin-3-yl)benzyloxy)nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(6-methoxy-4-methylpyridin-3-yl)benzyloxy)nicotinamide(1580504-38-6)
• EPA Substance Registry System: 2-(4-(6-methoxy-4-methylpyridin-3-yl)benzyloxy)nicotinamide(1580504-38-6)

Safety Data

• Hazardous Substances Data: 1580504-38-6(Hazardous Substances Data)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 503184-35-8 (6-methoxy-4-methylpyridin-3-yl)boronic acid 
• 10366-35-5 2-chloronicotinamide 

Relevant articles and documents

Biarylmethoxy nicotinamides as novel and specific inhibitors of mycobacterium tuberculosis

A whole cell based screening effort on a focused library from corporate collection resulted in the identification of biarylmethoxy nicotinamides as novel inhibitors of M. tuberculosis (Mtu) H37Rv. The series exhibited tangible structure-activity relationships, and during hit to lead exploration, a cellular potency of 100 nM was achieved, which is an improvement of >200-fold from the starting point. The series is very specific to Mtu and noncytotoxic up to 250 μM as measured in the mammalian cell line THP-1 based cytotoxicity assay. This compound class retains its potency on several drug sensitive and single drug resistant clinical isolates, which indicate that the compounds could be acting through a novel mode of action.