158076-64-3

Basic information

• Product Name: 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL
• Synonyms: 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL
• CAS NO: 158076-64-3
• Molecular Formula: C12H3Cl7O
• Molecular Weight: 411.32
• Mol File: 158076-64-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.6°Cat760mmHg
• Flash Point: 212.4°C
• Appearance: /
• Density: 1.736g/cm³
• CAS DataBase Reference: 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL(158076-64-3)
• EPA Substance Registry System: 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL(158076-64-3)

Safety Data

• Hazardous Substances Data: 158076-64-3(Hazardous Substances Data)

Usage

Description

2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is a chemical compound belonging to the polychlorinated biphenyls (PCBs) family. It is characterized by the presence of seven chlorine atoms in specific positions on the biphenyl structure. 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL has been widely studied due to its environmental and health implications.

Uses

Used in Environmental Testing and Research:
2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is used as a standard for environmental testing and research. It helps in understanding the presence and effects of PCBs in the environment, as well as their impact on human health.
Used in Studies on Thyroid Hormone Levels:
In the field of endocrinology, 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is used to study the effects of PCBs on serum thyroid hormone levels in pregnant women and their infants. This is important for understanding the potential developmental and health risks associated with PCB exposure.
Used in Research on Deiodinase Activity:
2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is also used in research on polychlorinated biphenyl exposure and its effects on deiodinase activity in young infants. Deiodinases are enzymes involved in the regulation of thyroid hormone levels, and understanding their interaction with PCBs can provide insights into the potential health risks of exposure to these chemicals.
Used in Metabolite Research:
Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs, including 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL, through cytochrome P450 enzyme-mediated oxidation. Research on these metabolites helps in understanding the toxicological effects and environmental fate of PCBs.

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Relevant articles and documents

Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum

Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3',4',5-pentachloro-4-biphenylol, 2,3',4,4',5-pentachloro-3-biphenylol, 2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4'-pentachloro-3-biphenylol, 2,2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4',5-hexachloro-3-biphenylol, 2,2',3,4',5,5'-hexachloro-4-biphenylol, 2,2',3,3',4',5,5'-heptachloro-4-biphenyl 2,2',3',4,4',5,5'-heptachloro-3-biphenylol, 2,2',3,4',5,5',6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.