158144-79-7

Basic information

• Product Name: 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE
• Synonyms: 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE;TERT-BUTYL 4-CYANO-4-PHENYLPIPERIDINE-1-CARBOXYLATE;1-Boc-4-cyano-4-phenylpiperidine;Tert-butyl 4-cyano-4-phenyl-1-piperidinecarboxylate
• CAS NO: 158144-79-7
• Molecular Formula: C₁₇H₂₂N₂O₂
• Molecular Weight: 286.38
• Mol File: 158144-79-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE(158144-79-7)
• EPA Substance Registry System: 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE(158144-79-7)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 158144-79-7(Hazardous Substances Data)

Usage

General Description

1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE is an organic compound with the chemical formula C19H22N2O2. The compound belongs to the subclass of piperidines, which are cyclic amines containing a six-membered ring with nitrogen. Being BOC-protected, it is often in a solid form and used prominently in the field of organic chemistry, specifically in the synthesis or manufacturing of other complex compounds. As a custom synthesis material, it is primarily used for research purposes and not naturally found in the environment. Proper handling of this chemical compound is necessary due to its reactivity and potential health hazards. The precise properties such as boiling, melting points, and specific weight generally depends on multiple factors such as purity and environmental conditions.

InChI:InChI=1S/C17H22N2O2/c1-16(2,3)21-15(20)19-11-9-17(13-18,10-12-19)14-7-5-4-6-8-14/h4-8H,9-12H2,1-3H3

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 51304-58-6 4-cyano-4-phenylpiperidine hydrochloride 
• 140-29-4 phenylacetonitrile 
• 71999-74-1 tert-butyl N-(2-chloroethyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 40481-13-8 4-phenyl-4-cyanopiperidine 

Downstream Products

• 1071485-35-2 N-((1-(4-chloro-3-sulfamoylbenzoyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071485-37-4 N-((1-(1-aminocyclopropanecarbonyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071483-71-0 N-((1-(2-(dimethylamino)acetyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071484-39-3 3-fluoro-N-((1-(2-hydroxy-2-methylpropyl)-4-phenylpiperidin-4-yl)methyl)-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071484-33-7 N-((1-(2-cyanoethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071484-09-7 N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071485-16-9 methyl 4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)-4-phenylpiperidine-1-carboxylate hydrochloride 
• 1071484-22-4 N-((1-cyclopropyl-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071484-06-4 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide hydrochloride 
• 1071484-01-9 N-((1-acetyl-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride 
• 1071486-22-0 N-((1-(2-(dimethylamino)acetyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide 
• 1071483-40-3 tert-butyl 4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)-4-phenylpiperidine-1-carboxylate 
• 1071486-28-6 N-((1-(cyanomethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide 
• 1071485-75-0 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((1-(methylsulfonyl)-4-phenylpiperidin-4-yl)methyl)picolinamide 

Relevant articles and documents

PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Disclosed in the present disclosure are a pyrimidine-fused cyclic compound or a pharmaceutically acceptable salt, hydrate, prodrug, stereoisomer, solvate or isotope labeled compound thereof. Also provided in the present disclosure are a preparation method for the compound, a composition comprising the compound and a use of the compound for the preparation of a medicament for the prevention and/or treatment of a disease or condition associated with abnormal SHP2 activity.

Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity

Targeting of Akt has been validated as a well rationalized approach to cancer treatment, and represents a promising therapeutic strategy for aggressive hematologic malignancies. We describe herein an exploration of novel Akt inhibitors for cancer therapy through structural optimization of previously described 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives. Our studies yielded a novel series of pyrrolopyrimidine based phenylpiperidine carboxamides capable of potent inhibition of Akt1. Notably, 10h exhibited robust antiproliferative effects in both mantle cell lymphoma cell lines and primary patient tumor cells. Low micromolar doses of 10h induced cell apoptosis and cell cycle arrest in G2/M phase, and significantly downregulated the phosphorylation of Akt downstream effectors GSK3β and S6 in Jeko-1 cells.

HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.