15845-62-2 Usage
Description
4-IODOPHENYL ISOCYANATE is an organic compound with the chemical formula C7H4INO and is characterized by its reactivity and versatility in chemical synthesis. It is a valuable intermediate in the production of various pharmaceuticals and organic compounds due to its unique structure and properties.
Uses
Used in Pharmaceutical Industry:
4-IODOPHENYL ISOCYANATE is used as a key intermediate for the synthesis of various pharmaceutical compounds, such as silicon-stereogenic silicon-bridged arylpyridinones, N-(4-iodophenyl)cholesteryl-3-carbamate, and N-(4-iodophenyl)pregnenolone-3-carbamate. These compounds have potential applications in the treatment of various medical conditions and diseases.
Used in Chemical Synthesis:
4-IODOPHENYL ISOCYANATE is used as a versatile building block in the synthesis of a wide range of organic compounds. Its reactivity and unique structure make it a valuable component in the development of new materials and products across various industries, including pharmaceuticals, agrochemicals, and specialty chemicals.
Preparation
To a solution of triphosgene (3.0 g, 10 mmol) and triethylamine (2.02 g, 20 mmol) in dry benzene (30 mL), a solution of 4-iodoaniline (4.3 g, 20 mmol) in dry benzene (15 mL) was added over 20 min. During the course of the addition, the temperature of the reaction mixture was increased from ambient to reflux temperature. After refluxing for 3 h, the reaction mixture was filtered. The filtrate was concentrated to obtain a residue, which was subjected to distillation under reduced pressure to afford a colorless liquid. Yield 2.21 g (45.2%).
Check Digit Verification of cas no
The CAS Registry Mumber 15845-62-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,8,4 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15845-62:
(7*1)+(6*5)+(5*8)+(4*4)+(3*5)+(2*6)+(1*2)=122
122 % 10 = 2
So 15845-62-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H4INO/c8-6-1-3-7(4-2-6)9-5-10/h1-4H
15845-62-2Relevant articles and documents
Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes
Morishita, Kosuke,Okamoto, Yuna,Murayama, Shuhei,Usui, Kazuteru,Ohashi, Eriko,Hirai, Go,Aoki, Ichio,Karasawa, Satoru
, p. 7810 - 7817 (2017)
Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs), denoted as 1 and 2, composed of self-assembled ureabenzene derivatives possessing one or two amp
Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization
Hou, Zhong-Wei,Xu, Hai-Chao
supporting information, p. 394 - 398 (2020/03/04)
An electrochemical synthesis of oxazol-2-ones and imidazol-2-ones has been developed via 5-exo-dig cyclization of propargylic carbamates- and ureas-derived amidyl radicals. The electrosynthesis relies on the dual function of 2,2,6,6-tetramethylpiperidin- 1-yl)oxyl (TEMPO) as a redox mediator for amidyl radical formation and an oxygen atom donor. The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol-2-ones and imidazol-2-ones from readily available materials.
Electrochemical C?H/N?H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles
Hou, Zhong-Wei,Mao, Zhong-Yi,Zhao, Huai-Bo,Melcamu, Yared Yohannes,Lu, Xin,Song, Jinshuai,Xu, Hai-Chao
supporting information, p. 9168 - 9172 (2016/08/05)
Indoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble-metal- and oxidant-free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles.