158563-45-2

Basic information

• Product Name: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
• Synonyms: L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide;Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2;Melanostatine-5;Melanostatine-5(nonpeptide-1);melanostatine;Melitane / Nonapeptide-1;Melanostatine-5, Nonapeptide-1;Nonapeptide-1, Melanostatine-5, Melanostatine
• CAS NO: 158563-45-2
• Molecular Formula: C61H87N15O9S
• Molecular Weight: 1206.50358
• Mol File: 158563-45-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• Solubility: soluble in water(≥0.1g/ml)
• PKA: 13.32±0.46(Predicted)
• CAS DataBase Reference: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2(158563-45-2)
• EPA Substance Registry System: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2(158563-45-2)

Safety Data

• Hazardous Substances Data: 158563-45-2(Hazardous Substances Data)

Usage

Description

Nonapeptide-1 is a skin lightening peptide, derived from the melanocyte stimulating hormone (MSH). It prevents the activity of tyrosine in the melanocytes, melanin synthesis inhibition and helps to even out your skin tone by lessening hyper-pigmentation. This process reduces the formation of unwanted pigmentation, allowing for the control over skin tone and brown spots.

Uses

A skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

Application

skin radiance, skin Lightening-whitening, anti-dark spot

Definition

Nonapeptide-1 is one skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

benefits

Nonapeptide-1inhibits melanin production originally induced bya-MSH.Whitening, spot-removing as well as preventing hyperpigmentation.Its recommended dosage in skin care products is 0.5~3%.

Biological Functions

1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%

Biotechnological Applications

Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree[1].

storage

Common storage 2-8℃, long time storage -20℃.