158669-26-2 Usage
Description
4-Iodo-2-methoxypyridine-3-carboxaldehyde is an organic compound characterized by its unique molecular structure, which features an iodine atom at the 4-position, a methoxy group at the 2-position, and a carboxaldehyde group at the 3-position of a pyridine ring. 4-Iodo-2-methoxypyridine-3-carboxaldehyde is known for its potential applications in the pharmaceutical and chemical industries due to its versatile chemical properties.
Uses
Used in Pharmaceutical Industry:
4-Iodo-2-methoxypyridine-3-carboxaldehyde is used as a key intermediate in the synthesis of insulin-like growth factor 1-receptor (IGF-1R) inhibitors. These inhibitors are designed to target and block the activity of IGF-1R, which plays a crucial role in cell growth, proliferation, and survival. By inhibiting IGF-1R, these compounds can effectively suppress tumor growth and display anti-tumor activity, making them valuable in the development of cancer therapeutics.
In addition to its role in the synthesis of IGF-1R inhibitors, 4-Iodo-2-methoxypyridine-3-carboxaldehyde may also find applications in other areas of the pharmaceutical industry, such as the development of novel drugs targeting different receptors or enzymes involved in various diseases. Its unique chemical structure allows for further functionalization and modification, enabling the creation of new compounds with potential therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 158669-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,6,6 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 158669-26:
(8*1)+(7*5)+(6*8)+(5*6)+(4*6)+(3*9)+(2*2)+(1*6)=182
182 % 10 = 2
So 158669-26-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H6INO2/c1-11-7-5(4-10)6(8)2-3-9-7/h2-4H,1H3
158669-26-2Relevant articles and documents
Catalytic enantioselective synthesis of 20(S)-camptothecin: A practical application of the sharpless asymmetric dihydroxylation reaction
Fang,Xie,Lowery
, p. 6142 - 1643 (1994)
The first catalytic asymmetric route to 20(S)-camptothecin was achieved, using as the key steps a tandem intramolecular Heck reaction/olefin isomerization process and a Sharpless asymmetric dihydroxylation (AD) reaction.
INHIBITORS OF BETA SECRETASE
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Page/Page column 25; 26, (2018/09/28)
The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II) (I) and (II) and the tautomers and the stereoisomeric forms thereof, wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.
PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES
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Paragraph 0105, (2014/09/29)
Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Formula (I). Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.
