1590-21-2

Basic information

• Product Name: 4-NAPHTHALEN-2-YL-4-OXO-BUTYRIC ACID METHYL ESTER
• Synonyms: 4-NAPHTHALEN-2-YL-4-OXO-BUTYRIC ACID METHYL ESTER
• CAS NO: 1590-21-2
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• Mol File: 1590-21-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 408.3°C at 760 mmHg
• Flash Point: 182.5°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 7.1E-07mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 4-NAPHTHALEN-2-YL-4-OXO-BUTYRIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NAPHTHALEN-2-YL-4-OXO-BUTYRIC ACID METHYL ESTER(1590-21-2)
• EPA Substance Registry System: 4-NAPHTHALEN-2-YL-4-OXO-BUTYRIC ACID METHYL ESTER(1590-21-2)

Safety Data

• Hazardous Substances Data: 1590-21-2(Hazardous Substances Data)

Usage

General Description

4-Naphthalen-2-yl-4-oxo-butyric acid methyl ester is a chemical compound with the molecular formula C15H12O3. It is derived from naphthalene and is commonly used in the synthesis of pharmaceuticals and other organic compounds. 4-NAPHTHALEN-2-YL-4-OXO-BUTYRIC ACID METHYL ESTER is a methyl ester derivative of 4-oxo-butyric acid, and it has a variety of potential applications in the fields of medicine and chemical research. It is important to note that while this compound has potential uses, it must be handled and used with caution due to its potential for toxic and harmful effects on human health and the environment.

InChI:InChI=1/C15H14O3/c1-18-15(17)9-8-14(16)13-7-6-11-4-2-3-5-12(11)10-13/h2-7,10H,8-9H2,1H3

Upstream product

• 1590-22-3 4-(2-naphthyl)-4-oxobutyric acid 
• 77-78-1 dimethyl sulfate 
• 876656-48-3 methyl 4-hydroxy-4-(naphthalen-2-yl)but-2-ynoate 
• 93-09-4 naphthalene-2-carboxylate 
• 2243-83-6 2-naphthaloyl chloride 
• 76635-88-6 vinyl-2-naphthylcarbinol 
• 66-99-9 β-naphthaldehyde 
• 922-67-8 propynoic acid methyl ester 
• 91-20-3 naphthalene 
• 1490-25-1 succinic acid monomethylester chloride 
• 14213-56-0 methyl β-diazopropionate 
• 67-56-1 methanol 
• 575-36-0 1-acetamidonaphthalene 

Downstream Products

• 1202876-44-5 C₂₂H₁₈O₄ 
• 1202876-43-4 β-benzylidene-β-(2-naphthoyl)propionic acid 

Relevant articles and documents

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Electrophilic Substitution in Naphthalenes: Cyclisation of Naphthylbutanols to Tetrahydrophenanthrene

Both 4-(1-naphthyl)butanol and 4-(2-naphthyl)butanol cyclised in refluxing boron trifluoride-ether to give 1,2,3,4-tetrahydrophenanthrene.By use of the corresponding 1,1-dideuteriobutanol derivatives and analysis of the products by 220 MHz 1H n.m.r. spectroscopy it has been demonstrated that the 1-naphthylbutanol cyclises by two distinct pathways, (a) by direct attack (84percent) at the 2-position, and (b) by ipso-attack (16percent) at the 1-position of the naphthalene nucleus, followed by rearrangement.The 2-naphthylbutanol cyclises exclusively by direct substitution at the 1-position.With 4-(4-methoxy-1-naphthyl)-1,1-dideuteriobutanol on the other hand the proportion of ipso-substitution rises to 71 percent as shown by the 360 MHz 1H n.m.r. spectra of the resulting mixture of tetrahydrophenanthrenes.

Transition Metal-Free Alkyne-Aldehyde Reductive C?C Coupling trough Cascade Borylation/Olefin Isomerization

A direct approach to γ-keto esters through cascade alkyne-aldehyde reductive C?C coupling of propargyl esters and aromatic aldehydes under transition-metal-free (TM-free) fashion was developed. Compared with multistep processes, this procedure provides a

Mg(OMe)2 promoted allylic isomerization of γ-hydroxy-α,β-alkenoic esters to synthesize γ-ketone esters

This work concerns the Mg(OMe)2 promoted allylic isomerization of γ-hydroxy-α,β-alkenoic esters with TMEDA as an additive. The isomerization proceeded under mild conditions and afforded γ-keto esters in high yield (up to 96%) within 2 h. Both (Z)- and (E)-γ-hydroxy-α,β-alkenoic esters were tolerated under the reaction conditions. This transformation involves the in situ formation of a dienolate intermediate from the easily accessible γ-hydroxy-α,β-alkenoic ester. The in situ generated dienolate can react with benzaldehyde and undergo a practical, useful tandem allylic isomerization-Aldol reaction to afford more functionalized compounds.