1590417-65-4

Basic information

• Product Name: 4,6-Bis(4,4’-difluorobenzhydryl)-1,3-dimethoxybenzene
• Synonyms: 4,6-Bis(4,4’-difluorobenzhydryl)-1,3-dimethoxybenzene
• CAS NO: 1590417-65-4
• Molecular Weight: 542.573
• Mol File: 1590417-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,6-Bis(4,4’-difluorobenzhydryl)-1,3-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Bis(4,4’-difluorobenzhydryl)-1,3-dimethoxybenzene(1590417-65-4)
• EPA Substance Registry System: 4,6-Bis(4,4’-difluorobenzhydryl)-1,3-dimethoxybenzene(1590417-65-4)

Safety Data

• Hazardous Substances Data: 1590417-65-4(Hazardous Substances Data)

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 

Relevant articles and documents

Iron-catalyzed friedel-crafts benzylation with benzyl TMS ethers at room temperature

Friedel-Crafts benzylations between unactivated arenes and benzyl alcohol derivatives are clean and straightforward processes to construct biologically useful di- and triarylmethanes. We have established an efficient iron-catalyzed Friedel-Crafts benzylation method at room temperature that uses benzyl TMS ethers as substrates, which are poorly reactive under common nucleophilic substitution conditions. The reaction seems to progress through iron-catalyzed self-condensation of the benzyl TMS ether to the corresponding dibenzylic ether. The use of excess arene relative to benzyl TMS ether produced mono-benzylated arene (diand tri-arylmethane products), whereas the use of excess benzyl TMS ether versus arene provided bis-benzylated arene (polyarylated products) in high yields and regioselectivities. In previous methods, the latter double Friedel-Crafts benzylations hardly proceed.