159248-98-3Relevant articles and documents
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Roux, Florence,Maugras, Isabelle,Poncet, Joel,Niel, Gilles,Jouin, Patrick
, p. 5345 - 5360 (2007/10/02)
A stepwise synthesis of dolastatin 10 starting from the dolaphenine residue is described. The chiral dola isoleuine and dolaproine residues were obtained by 5-step procedures from the corresponding N-Boc amino acid. The key steps are respectively the NaBH4 reduction of an allylic ketone and the addition of an achiral Z-crotylboronate on the N-Boc-L-prolinal. Peptidic couplings were efficiently realised with reagents developed in the laboratory.