159496-16-9 Usage
Description
[1',2',3',4',5''-13C5]URIDINE is a labeled nucleoside, specifically a derivative of uridine, which is one of the four basic components of ribonucleic acid (RNA). The labeling with 13C isotopes at the 1', 2', 3', 4', and 5'' positions allows for enhanced detection and tracking in various applications.
Uses
Used in Biochemical Research:
[1',2',3',4',5''-13C5]URIDINE is used as a labeled compound for studying the structure, function, and interactions of RNA molecules in biochemical research. The incorporation of 13C isotopes enables researchers to track the molecule's behavior and interactions with other biomolecules using advanced analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [1',2',3',4',5''-13C5]URIDINE is used as a labeled reference material for the development and validation of new drugs targeting RNA-related diseases. The labeled uridine can be used to monitor the efficacy and specificity of these drugs in preclinical and clinical studies.
Used in Diagnostic Applications:
[1',2',3',4',5''-13C5]URIDINE is used as a diagnostic marker in the development of new diagnostic tools and tests for RNA-related diseases. The labeled compound can be incorporated into diagnostic assays to improve the sensitivity and accuracy of disease detection.
Used in Metabolic Studies:
In the field of metabolism, [1',2',3',4',5''-13C5]URIDINE is used as a labeled tracer for studying the metabolic pathways and fluxes involving uridine and RNA in cells. The 13C labeling allows for the tracking of uridine metabolism and its role in various cellular processes using mass spectrometry and other analytical techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 159496-16-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,4,9 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 159496-16:
(8*1)+(7*5)+(6*9)+(5*4)+(4*9)+(3*6)+(2*1)+(1*6)=179
179 % 10 = 9
So 159496-16-9 is a valid CAS Registry Number.
159496-16-9Relevant articles and documents
Synthesis of multiply labelled ribonucleosides for sequence-specific labelling of oligo-RNA
Milecki, Jan,Foeldesi, Andras,Fischer, Artur,Adamiak, Ryszard W.,Chattopadhyaya, Jyoti
, p. 763 - 783 (2007/10/03)
The synthesis of ribonucleotide blocks multiply labelled with 2H, 13C and 15N for solid support synthesis of sequence specifically labelled RNA is described. Labels were introduced in the ribose ring (13C), C5 position of pyrimidine nucleobases (2H) and exocyclic amino groups (15N) and serve as multiple probes for studying the various physicochemical consequences of physiologically important RNA folding by high-resolution multi-nuclear NMR spectroscopy.
Chemical Synthesis of 13C-labelled Monomers for the Solid-Phase and Template Controlled Enzymatic Synthesis of DNA and RNA Oligomers
Quant, S.,Wechselberger, R. W.,Wolter, M. A.,Woerner, K.-H.,Schell, P.,et al.
, p. 6649 - 6652 (2007/10/02)
The preparation of 13C-labelled ribonucleosides starting from -glucose 1 and the corresponding nucleobases 5a-e or 6a-e (N6-benzoyl-adenine, N2-acetyl-guanine, N4-benzoyl-cytosine, uracil and thymine) in 47-66percent overall yield is described.Their subsequent transformation into 5'-O-dimethoxytrityl protected DNA-phosphoramidites and 5'-O-dimethoxytrityl-2'-O-trialkylsilyl protected RNA-phosphor-amidites for the solid phase synthesis of DNA- and RNA-oligomers and to 5'-O-ribo- and deoxyribo-nucleosidetriphosphates for template controlled enzymatic synthesis (polymerase- or reverse transcriptase reaction) has been carried out.
