1596118-31-8

Basic information

• Product Name: C₂₁H₃₄N₂O₃
• Synonyms: C₂₁H₃₄N₂O₃
• CAS NO: 1596118-31-8
• Molecular Weight: 362.513
• Mol File: 1596118-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₃₄N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₃₄N₂O₃(1596118-31-8)
• EPA Substance Registry System: C₂₁H₃₄N₂O₃(1596118-31-8)

Safety Data

• Hazardous Substances Data: 1596118-31-8(Hazardous Substances Data)

Upstream product

• 10335-68-9 dodecanehydroxamic acid 
• 6591-61-3 (S)-Phenylglycine methyl ester 

Relevant articles and documents

Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate-mediated lossen rearrangement: Single-pot racemization-free synthesis of hydroxamic acids and ureas from carboxylic acids

Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the synthesis of ureas is demonstrated. Required hydroxamic acids for the Lossen rearrangements were synthesized from carboxylic acids using the same reagent. Finally, reaction of an amine with the produced isocyanate resulted in urea. Good yields without racemization were achieved under milder and simpler reaction conditions. Reactions are compatible with common N-protecting groups, such as Boc, Fmoc, Cbz, and benzyl, as well as various OH protecting groups, such as tBu and Bzl. Conversion from carboxylic acid to urea is achieved in one pot. Most importantly, byproducts Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] and 4-nitrobenzenesulfonic acid can be recovered easily and can be recycled to prepare the reagent. Thus, the method is environmentally friendly and cost-effective.