1597-33-7

Basic information

• Product Name: 3-Amino-2-fluoropyridine
• Synonyms: 3-AMINO-2-FLUOROPYRIDINE;2-FLUORO-PYRIDIN-3-YLAMINE;2-Fluoro-3-aminopyridine;2-FLUOROPYRIDIN-3-AMINE;3-Amino-2-Fluoropyrine;3-AMINO-2-FLUOROPYIDINE;3-AMINE-2-FLUOROPYRIDIN;1597-33-7
• CAS NO: 1597-33-7
• Molecular Formula: C₅H₅FN₂
• Molecular Weight: 112.1050032
• EINECS: 145-896-5
• Product Categories: Pyridine;Pyridines
• Mol File: 1597-33-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 102°C/18mmHg(lit.)
• Flash Point: >110℃
• Appearance: /
• Density: 1.212
• Refractive Index: 1.563
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.18±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-fluoropyridine(1597-33-7)
• EPA Substance Registry System: 3-Amino-2-fluoropyridine(1597-33-7)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-36/37/38-36-22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1597-33-7(Hazardous Substances Data)

Usage

Uses

3-Amino-2-fluoropyridine is a fluorinated building block and a useful research chemical for the preparation of other aromatic fluorinated compounds.

InChI:InChI=1/BF4.Ca/c2-1(3,4)5;/q-1;+2

Upstream product

• 1480-87-1 2-fluoro-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 1257881-52-9 (2-fluoro-pyridin-3-yl)-carbamic acid phenyl ester 
• 1089330-70-0 2-fluoropyridine-3-sulfonyl chloride 
• 1285515-59-4 2-{[(2,4-difluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide 
• 1285515-56-1 2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide 
• 1285514-28-4 N-(2-fluoro-3-pyridinyl)-2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzamide 
• 850220-97-2 6-bromo-2-fluoropyridin-3-amine 
• 104149-51-1 dihydro-5,6 oxo-6 pyrido<2,3-e>pyrrolo<1,2-a>pyrazine 

Relevant articles and documents

The ortho effect in pyridines. Part XI(1). Substituent effects on basicity of 2- and 4-substituted 3-aminopyridines

The substituent effects on the pKa values corresponding to the first protonation site of thirty 2- and 4-substituted 3-aminopyridines have been studied.It was found that the relative localized and delocalized effects are apparently sensitive to the variation of substituent position in the pyridine ring.An interaction of the 2-substituent with the protonation centre has mainly inductive character, whereas, the pKa values of 4-substituted 3-aminopyridines are highly affected by through-resonance.The steric effect was found to be insignificant.Keywords: substituent effects / 2- and 4-substituted 3-aminopyridines / basicity