159768-50-0

Basic information

• Product Name: Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate
• Synonyms: Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate;4-Fluoro-5-methoxy-2-nitro-benzoic acid methyl ester
• CAS NO: 159768-50-0
• Molecular Formula: C₉H₈FNO₅
• Molecular Weight: 229.1619232
• Mol File: 159768-50-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate(159768-50-0)
• EPA Substance Registry System: Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate(159768-50-0)

Safety Data

• Hazardous Substances Data: 159768-50-0(Hazardous Substances Data)

Usage

General Description

Methyl 4-fluoro-5-methoxy-2-nitrobenzoate is a chemical compound with the molecular formula C9H8FNO5. It is an ester derivative of 2-nitrobenzoic acid, with a methyl group attached to the ester functional group and fluoro and methoxy substituents at the 4th and 5th positions, respectively, on the benzene ring. Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate may be used in organic synthesis and pharmaceutical research due to its unique structure and potential pharmacological properties. However, it should be handled with caution as it may pose health hazards if not used properly, as it is a nitro compound and may have biological activity as a result of the presence of the methoxy and fluoro substituents.

Upstream product

• 7664-93-9 sulfuric acid 
• 74385-37-8 methyl 4-fluoro-3-methoxy-benzoate 
• 159768-48-6 4-chloro-7-fluoro-6-methoxyquinazoline 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 

Downstream Products

• 162012-60-4 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline 
• 159768-48-6 4-chloro-7-fluoro-6-methoxyquinazoline 
• 869475-52-5 7-fluoro-6-methoxyquinazolin-4-ol 
• 159768-51-1 2-amino-4-fluoro-5-methoxybenzoic acid methyl ester 

Relevant articles and documents

Pyrazole derivative for FGFR inhibitor and preparation method of pyrazole derivative

The invention provides a pyrazole derivative for an FGFR inhibitor and a preparation method of the pyrazole derivative. The invention specifically relates to an amide pyrazole compound serving as an FGFR irreversible inhibitor, and a preparation method and application thereof. The present invention provides a compound as shown in Formula I, or a pharmaceutically acceptable salt, or solvate, isotope substitute, prodrug, or metabolite thereof. The compound as shown in general formula I have FGFR inhibitory activity, and is capable of preventing or treating disorders associated with FGFR activityor expression, preferably such as cancer.

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors

Fibroblast growth factor receptors (FGFRs) are important oncology targets due to the dysregulation of this signaling pathway in a wide variety of human cancers. We identified a series of pyrazolylaminoquinazoline derivatives as potent FGFR inhibitors with low nanomolar potency. The representative compound 29 strongly inhibited FGFR1-3 kinase activity and suppressed FGFR signaling transduction in FGFR-addicted cancer cells; FGFRs-driven cell proliferation was also strongly inhibited regardless of mechanistic complexity implicated in FGFR activation, which further confirmed that 29 was a potent pan-FGFR inhibitor. The flexibility of our structure offered the potential to preserve good affinity for mutant FGFR, which is important for developing TKIs with long-term efficacy.

Facile synthesis of 7-amino anilinoquinazolines via direct amination of the quinazoline core

The facile preparation of 4-(3-chloro-4-fluoroanilino)-6-alkoxy-7- aminoquinazolines from their corresponding 7-triflate and 7-fluoro precursors are highlighted.