159898-15-4Relevant articles and documents
1,9-dimetalated β-Carbolines. Versatile Building Blocks for the Total Synthesis of Alkaloids
Bracher, Franz,Hildebrand, Dirk
, p. 12329 - 12336 (1994)
Reactions of the dimetalated β-carboline 6, prepared from 1-bromo-β-carboline (4), with electrophiles are key steps in the syntheses of various β-carboline alkaloids.Transmetalation of 6 with ZnCl2 followed by palladium-catalyzed cross coupling reaction with 2-chloroquinoline gave the alkaloid nitramarine (14).
Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines
Ma, Chunming,Cao, Rihui,Shi, Buxi,Zhou, Xiantai,Ma, Qin,Sun, Jie,Guo, Liang,Yi, Wei,Chen, Zhiyong,Song, Huacan
scheme or table, p. 5513 - 5519 (2010/12/20)
The condensation of alkylenediamine with ethyl β-carboline-1- carboxylate and 1-bromo-β-carboline gave β-carboline-1-carboxamides and 1-amino-β-carbolines, respectively. Some of these β-carbolines were active against a panel of human tumor cell lines, and 1-amino derivatives were more potent than their 1-carboxamide congeners. In particular, among the 1-amino-β-carbolines, the N9-arylated alkyl substituted β-carbolines exhibited the most interesting cytotoxic activities with IC50 value of lower than 20 μM. The preliminary structure-activity relationships (SARs) analysis suggested that (1) 1-amino substituents were the advisable pharmacophoric group for enhanced cytotoxic activities; (2) the introduction of appropriate arylated alkyl groups into position-9 of β-carboline facilitated their cytotoxic potencies.
