1599466-89-3

Basic information

• Product Name: t-BuXphos Palladacycle Gen. 4
• Synonyms: Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct, min;Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct;Methanesulfonato(2-Di-t-butylphosphino-2,4,6-tri-i-propyl-1,1-biphenyl)(2-methylamino-1,1-biphenyl-2-yl)palladium(II);Methanesulfonato(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct, [t-BuXphos Palladacycle Gen. 4]
• CAS NO: 1599466-89-3
• Molecular Formula: C44H62Cl2NO3PPdS
• Molecular Weight: 893.332741
• Product Categories: Buchwald Ligands&Precatalysts;Buchwald Precatalysts Series;Pd
• Mol File: 1599466-89-3.mol
• Article Data: 1

Chemical Properties

• Appearance: off-white to gray/Powder
• CAS DataBase Reference: t-BuXphos Palladacycle Gen. 4(CAS DataBase Reference)
• NIST Chemistry Reference: t-BuXphos Palladacycle Gen. 4(1599466-89-3)
• EPA Substance Registry System: t-BuXphos Palladacycle Gen. 4(1599466-89-3)

Safety Data

• Hazardous Substances Data: 1599466-89-3(Hazardous Substances Data)

Usage

Reaction

Alternative N-methyl catalyst for mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media.

Upstream product

• 1581285-85-9 (2′-methylamino-1,1′-biphenyl-2-yl)methanesulfonatopalladium(II) dimer 
• 564483-19-8 tert-butyl XPhos 

Relevant articles and documents

N-substituted 2-aminobiphenylpalladium methanesulfonate precatalysts and their use in C-C and C-N cross-couplings

A series of phosphine-ligated palladium precatalysts based on N-methyl- and N-phenyl-2-aminobiphenyl have been developed. Substitution at the nitrogen center prevents the presence of traces of aminobiphenyls that contain a free -NH2 group from contaminating cross-coupling products. These precatalysts produce N-substituted carbazoles upon activation, which cannot consume starting materials. These precatalysts were efficiently generated from 2-aminobiphenyl with minimal purification and found to be highly effective in Suzuki-Miyaura and C-N cross-coupling reactions.