159981-19-8

Basic information

• Product Name: 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE
• Synonyms: 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE;6-(2,2,2-Trifluoroethoxy)nicotinaldehyde
• CAS NO: 159981-19-8
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.13
• Mol File: 159981-19-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 239.8°C at 760 mmHg
• Flash Point: 98.9°C
• Appearance: /
• Density: 1.356g/cm³
• Vapor Pressure: 0.0392mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.97±0.22(Predicted)
• CAS DataBase Reference: 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE(159981-19-8)
• EPA Substance Registry System: 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE(159981-19-8)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41-43
• Safety Statements: 26-36/37-39
• Hazardous Substances Data: 159981-19-8(Hazardous Substances Data)

Usage

General Description

6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde, also known as CAS Number 188123-71-4, is a chemical compound belonging to the group of pyridines. It's known for its particular chemical structure, which contains a pyridine ring substituted with a trifluoroethoxy group at one position, and a formyl group at another. 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE is used in the preparation of various pharmaceuticals and other organic compounds due to its special reactivity and stability offered by the electron-withdrawing trifluoroethoxy group. However, specific details about its physical properties or toxicity are not widely available due to its specialized use.

InChI:InChI=1/C8H6F3NO2/c9-8(10,11)5-14-7-2-1-6(4-13)3-12-7/h1-4H,5H2

Upstream product

• 287979-27-5 6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 1373862-15-7 N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide 

Relevant articles and documents

AZETIDINE COMPOUNDS AS GRP119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS

The present disclosure relates to azetidine compounds. The azetidine compounds are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The present disclosure furthermore relates to the use of azetidine compounds as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND

There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group, RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula -CR11R12-, -CO-, -CO-O-, or -CO-NH-, W represents a single bond or a C1-3 alkylene group, and Ring B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group, Y represents a nitrogen atom or the formula N+(RF), RF represents a C1-4 alkyl group, and m and n, which may be the same or different, each represent an integer of 0 or 1.