160009-36-9

Basic information

• Product Name: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate
• Synonyms: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate;4-(4-Fluorophenyl)-2-(MethylaMino)-6-(1-Methylethyl)-5-pyriMidinecarboxylic Acid Methyl Ester;5-PyriMidinecarboxylic acid,4-(4-fluorophenyl)-2-(MethylaMino)-6-(1-Methylethyl)-, Methyl ester;Z-5 Methyl 4-(4-fluorophenyl)-6-isopropyl-2-
• CAS NO: 160009-36-9
• Molecular Formula: C₁₆H₁₈FN₃O₂
• Molecular Weight: 303.3314232
• Product Categories: Amines;Aromatics;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds
• Mol File: 160009-36-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate(160009-36-9)
• EPA Substance Registry System: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate(160009-36-9)

Safety Data

• Hazardous Substances Data: 160009-36-9(Hazardous Substances Data)

Usage

Uses

An intermediate of Rosuvastatin (R700500).

Upstream product

• 904743-93-7 methyl 2-(4-fluorobenzoyl)-3-methoxy-3-isopropylpropenoate 
• 22661-87-6 1-methylguanidine hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 1184-85-6 N-methylmethane sulphonamide 
• 488798-38-5 2-chloro-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid methyl ester 
• 122549-26-2 methyl 2-(4-fluorophenyl)methylidene-3-oxo-4-methylpentanoate 
• 799842-06-1 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylic acid methyl ester 
• 74-89-5 methylamine 

Downstream Products

• 289042-11-1 methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate 

Relevant articles and documents

Method for continuously preparing rosuvastatin intermediate by micro-channel modular reaction device

The invention discloses a method for continuously preparing a rosuvastatin intermediate by a micro-channel modular reaction device. The method includes the steps: performing reaction on isopropanol solution of fluorobenzaldehyde and isopropanol solution o

METHOD FOR PRODUCING PYRIMIDINE COMPOUND

Compound (II) and compound (III) are reacted to give compound (IVa) and/or compound (IVb); which are/is then reacted with compound (V) to give compound (I). wherein X is a methylthio group and the like, R1 and R2 are each a lower alkyl group optionally having substituent(s), an aryl group optionally having substituent(s) and the like, R3 is a lower alkyl group, R4 is a hydrogen atom, a lower alkyl group optionally having substituent(s) and the like, and Q is a carboxylate group and the like.

PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES

There is described a process for the preparation of compounds of formula (1) starting from the reaction of the compounds of formulae (24), (25) and (26) to form the compound of formula (23), wherein in each case R1, R2 and R3 are each independently of the others an unsubstituted or substituted organic radical; R4 is hydrogen, unsubstituted or substituted C1-C8alkyl, C1-C8alkoxy, phenoxy or benzyloxy, or halogen; Y1 and Y2 are each independently of the other hydrogen or a protecting group, or Y1 and Y2 together are a protecting bridge; and X1 is hydrogen, an organic radical or a cation; and also novel intermediates.