160145-82-4Relevant articles and documents
A facile and scaleable synthesis of 3-O-decladinose-6-methyl-10,11- dehydrate-erythromycin-3-one-2′-acetate, an important intermediate for ketolide synthesis
Wei, Xin,You, Qidong
, p. 446 - 449 (2006)
A facile and scaleable synthetic process of compound 2, an important intermediate for synthesis of ketolide semisynthetic antibiotics, was developed starting from commercially available clathromycin with an overall yield of ~74%. This synthetic pathway wa
Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains
Zhao, Zhe-hui,Zhang, Xiao-xi,Jin, Long-long,Yang, Shuang,Lei, Ping-sheng
, p. 2358 - 2363 (2018/06/25)
A series of quinoylalkyl side chains was designed and synthesized, followed by introduction into ketolides by coupling with building block 6 or 32. The corresponding targets 7a–n, 33b, and 33e were tested for their in vitro activities against a series of macrolide-sensitive and macrolide-resistant pathogens. Some of them showed a similar antibacterial spectrum and comparable activity to telithromycin. Among them, two C2-F ketolides, compounds 33b and 33e, displayed excellent activities against macrolide-sensitive and macrolide-resistant pathogens.
Erythromycin A ketolide antibiotic derivatives containing quinoline substituent group, and preparation methods and applications thereof
-
, (2016/10/08)
The invention discloses a series of erythromycin A ketolide antibiotic derivatives containing quinoline substituent group, represented by a formula I. The invention also provides preparation methods and applications of the derivatives, and side-chain inte