160230-47-7

Basic information

• Product Name: (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester
• Synonyms: (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester
• CAS NO: 160230-47-7
• Molecular Weight: 533.689
• Mol File: 160230-47-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester(160230-47-7)
• EPA Substance Registry System: (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester(160230-47-7)

Safety Data

• Hazardous Substances Data: 160230-47-7(Hazardous Substances Data)

Upstream product

• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 160232-08-6 (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol 
• 72225-62-8 N-(4-Isobutylsulfamoyl-phenyl)-acetamide 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 

Downstream Products

• 169280-56-2 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide 
• 206361-99-1 darunavir 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF DARUNAVIR

The present invention provides a cost effective and industrially feasible process for preparation of Darunavir (I). Also described is the novel salt of intermediate 4-Amino-N- ((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzene sulfonamide acid salt (VIII) and its use in the preparation of Darunavir. Formula (I) and (VII).

PROCESS FOR THE PREPARATION OF SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS

The present invention relates to a process for the preparation of sulfonamides useful as retroviral protease inhibitors.