160256-75-7Relevant articles and documents
Cationic lipid molecule, and application thereof in nucleic acid delivery
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Paragraph 0162; 0163; 0166; 0167, (2019/10/08)
The present invention discloses a cationic lipid molecule, and an application thereof in nucleic acid delivery. The structural formula of the cationic lipid molecule is represented by formula i. The invention further provides a cationic liposome, a lipid compound, a reagent, a kit, a preparation and a medicinal composition based on the cationic lipid molecule. The cationic lipid molecule has the advantages of simple synthesis process and good stability, and the cationic liposome has a high efficiency (characterized by high transfection efficiency) and a low toxicity, is stable and uniform, is easy to prepare, and can be used for transferring various cell lines. The cationic lipid molecule has excellent transitivity, and can efficiently deliver active substances (such as exemplary siRNA) omto cells (such as exemplary lung cancer cells), tissues and organs to achieve efficient regulation of the active substances. The problem that the toxicity and the transfer efficiency of cationic liposome existing in the prior art are low is solved.
Single-molecule imaging of platinum ligand exchange reaction reveals reactivity distribution
Esfandiari, N. Melody,Wang, Yong,Bass, Jonathan Y.,Cornell, Trevor P.,Otte, Douglas A. L.,Cheng, Ming H.,Hemminger, John C.,McIntire, Theresa M.,Mandelshtam, Vladimir A.,Blum, Suzanne A.
supporting information; experimental part, p. 15167 - 15169 (2010/12/20)
Single-molecule fluorescence microscopy provided information about the real-time distribution of chemical reactivity on silicon oxide supports at the solution-surface interface, at a level of detail which would be unavailable from a traditional ensemble technique or from a technique that imaged the static physical properties of the surface. Chemical reactions on the surface were found to be uncorrelated; that is, the chemical reaction of one metal complex did not influence the location of a future chemical reaction of another metal complex.
INSULIN DERIVATIVES CONJUGATED WITH STRUCTURALLY WELL DEFINED BRANCHED POLYMERS
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Page/Page column 69, (2008/06/13)
Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.