1602732-02-4Relevant articles and documents
Identification of novel SIRT2-selective inhibitors using a click chemistry approach
Tatum, Prima R.,Sawada, Hideyuki,Ota, Yosuke,Itoh, Yukihiro,Zhan, Peng,Ieda, Naoya,Nakagawa, Hidehiko,Miyata, Naoki,Suzuki, Takayoshi
, p. 1871 - 1874 (2014/04/17)
A series of 114 SIRT inhibitor candidates was assembled using 'click chemistry', by reacting two alkynes bearing 2-anilinobenzamide pharmacophore with 57 azide building blocks in the presence of Cu(I) catalyst. Screening identified two SIRT2-selective inhibitors, which were more SIRT2-selective than AGK2, a known SIRT2 inhibitor. These findings will be useful for further development of SIRT2-selective inhibitors.
