1603-41-4Relevant articles and documents
Mild, General, and Regioselective Synthesis of 2-Aminopyridines from Pyridine N -Oxides via N -(2-Pyridyl)pyridinium Salts
Xiong, Hui,Hoye, Adam T.
supporting information, p. 371 - 375 (2022/01/27)
A synthesis of 2-aminopyridines from pyridine N-oxides via their corresponding N-(2-pyridyl)pyridinium salts has been demonstrated and investigated. The reaction sequence features a highly regioselective conversion of the N-oxide into its pyridinium salt
Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters
Ronson, Thomas O.,Renders, Evelien,Van Steijvoort, Ben F.,Wang, Xubin,Wybon, Clarence C. D.,Prokopcová, Hana,Meerpoel, Lieven,Maes, Bert U. W.
supporting information, p. 482 - 487 (2019/01/04)
A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 by-product can be recycled.
Method for preparing 2-amino-5-methylpyridine through ammoniation of 3-methylpyridine
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Paragraph 0024; 0025; 0026; 0027; 0028; 0029; 0030-0035, (2017/08/28)
The invention discloses a method for preparing 2-amino-5-methylpyridine through ammoniation of 3-methylpyridine. The method comprises the following steps: placing a solvent, metallic sodium, a catalyst, an additive and the raw material 3-methylpyridine in a high-pressure reaction container, carrying out heating to 50 to 80 DEG C, then slowly adding liquefied ammonia and carrying out pressurization for a reaction; continuing pressurization to 3 to 6 MPa and heating to 150 to 190 DEG C and continuing the reaction; and terminating the reaction until no obvious pressure increase occurs during the reaction. According to the invention, a one-pot process is employed, and hydrolysis, liquid separation and rectification are successively carried out so as to produce 2-amino-5-methylpyridine and byproduce 2-amino-3-methylpyridine, wherein a ratio of 2-amino-5-methylpyridine to 2-amino-3-methylpyridine is in a range of (9-20): 1. The method has a high 3-methylpyridine conversion rate; the selectivity of the obtained 2-amino-5-methylpyridine can reach 90% or above; and the yield of 2-amino-5-methylpyridine can be increased to 84.5% or above.