160315-09-3Relevant articles and documents
Studies on Pyrazines. Part 28. Deoxydative Acetoxylation of Pyrazine N-Oxides
Sato, Nobuhiro,Miwa, Naoko,Suzuki, Hiroko,Sakakibara, Tohru
, p. 1229 - 1234 (2007/10/02)
Deoxydative acetoxylation of 3-methoxy-, 3-phenyl-, 3-methyl-, 3-chloro-, and 3-methoxycarbonylpyrazine 1-oxides furnished predominantly 2-acetoxy-6-substituted pyrazines, some of which were more selectively prepared by addition of zinc bromide and triethylamine to the reaction.Regioselectivity of the acetoxylation is discussed based upon heat of formation by AM1 and AM1-COSMO for all possible isomers of each set.