1604008-11-8

Basic information

• Product Name: (R)-(+)-tert-butyl 3-benzyl-2-oxopiperidine-1-carboxylate
• Synonyms: (R)-(+)-tert-butyl 3-benzyl-2-oxopiperidine-1-carboxylate
• CAS NO: 1604008-11-8
• Molecular Weight: 289.375
• Mol File: 1604008-11-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-(+)-tert-butyl 3-benzyl-2-oxopiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-tert-butyl 3-benzyl-2-oxopiperidine-1-carboxylate(1604008-11-8)
• EPA Substance Registry System: (R)-(+)-tert-butyl 3-benzyl-2-oxopiperidine-1-carboxylate(1604008-11-8)

Safety Data

• Hazardous Substances Data: 1604008-11-8(Hazardous Substances Data)

Upstream product

• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 100-52-7 benzaldehyde 
• 1604008-02-7 (E)-tert-butyl 3-benzylidene-2-oxopiperidine-1-carboxylate 
• 53031-80-4 (E)-3-phenylmethylene-2-piperidinone 
• 24424-99-5 di-tert-butyl dicarbonate 
• 94363-58-3 1-(2,2,2-Trifluoro-acetyl)-piperidin-2-one 
• 675-20-7 piperidin-2-one 

Relevant articles and documents

Chiral bidentate nitrogen phosphine ligand Rong-Phos iridium complex and high-enantioselectivity construction and application of nitrogen chiral center thereof

The invention discloses a chiral bidentate nitrogen phosphine ligand Rong-Phos iridium complex shown as a formula (2) and a high-enantioselectivity construction method and application and applicationof a nitrogen chiral center thereof. The iridium complex has a carbon chiral center and a nitrogen chiral center at the same time and is stable in property. According to the invention, a method for high-enantioselectivity construction of the nitrogen atom center of the iridium complex is adopted, and a pair of diastereoisomer catalysts, with different nitrogen center chirality, of the iridium complexes are applied to asymmetric hydrogenation reactions of cyclic unsaturated carbonyl compounds; and the iridium complex also has excellent reaction activity and enantioselectivity in asymmetric hydrogenation reactions of other cyclic unsaturated carbonyl compounds, and the iridium complex remarkable and excellent effect and shows scientific research value and wide application prospects.

Rhodium-catalyzed asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds

A highly enantioselective hydrogenation of exocyclic α,β-unsaturated carbonyl compounds catalyzed by Rh/bisphosphine-thiourea (ZhaoPhos) has been developed, giving the corresponding α-chiral cyclic lactones, lactams and ketones with high yields and excellent enantioselectivities (up to 99% yield and 99% ee). Remarkably, the hydrogen bond between the substrate and the catalyst plays a critical role in this transformation. The synthetic utility of this protocol has been demonstrated by efficient synthesis of chiral 3-(4-fluorobenzyl)piperidine, a key chiral fragment of bioactive molecules.