16051-77-7Relevant articles and documents
Active oxygen responsive antioxidant nitric oxide donor, and preparation method and application thereof
-
Paragraph 0028, (2021/08/14)
The invention relates to the field of medicinal chemistry, and especially relates to an active oxygen responsive antioxidant nitric oxide donor, and a preparation method and application thereof. The donor has a structural formula shown in the specification. The preparation method comprises the following steps: reacting PBAP with CDI to obtain PBAP-CDI; and reacting with ISN under the action of a catalyst to obtain the antioxidant nitric oxide donor. The active oxygen responsive antioxidant nitric oxide donor disclosed by the invention is good in stability and long in half-life period in a physiological environment, can be decomposed and released only under the stimulation of high-concentration active oxygen in inflammatory tissues, and does not generate side effects on normal tissues. Meanwhile, active oxygen can be effectively removed, and the anti-oxidation effect is achieved; and the antioxidant nitric oxide donor can promote the growth of endothelial cells and inhibit the growth of smooth muscle cells, is beneficial to rapid endothelialization of heart and blood vessels, has diversified functions, can be widely applied to drug development, and has popularization and application values.
Retinoic acid derivative based on NO donor and preparation method and application of retinoic acid derivative
-
Paragraph 0032-0034, (2021/02/10)
The invention provides a retinoic acid derivative based on an NO donor and a preparation method and application of the retinoic acid derivative. A series of novel multi-target retinoic acid derivatives are designed and synthesized by taking a multi-target drug theory as guidance, taking Am580 as a parent nucleus, combining structural characteristics of Am580 to select organic nitrate NO donors asNO sources, performing chemical modification on the NO donors to obtain a series of different donors and coupling ester or amido bonds with the parent nucleus. Tests show that the retinoic acid derivatives are higher in activity, lower in toxic and side effects and better in anti-tumor effect. The structural general formula of the retinoic acid derivative based on the NO donor provided by the invention is shown as a formula (I),.
An Improved Process for Industrial Production of Isosorbide-5-mononitrate: Recycling of Wastes
Zhu, Shi-Guo,Yang, Jiang-Tao,Zhang, Gui-Min,Chen, Cheng-Fu,Zhang, Fu-Li
supporting information, p. 991 - 995 (2018/08/03)
Different schemes were studied for the recovery of wastes generated during the industrial production of isosorbide-5-mononitrate (IS-5-MN). For the wastewater, disposal was achieved by hydrolysis of isosorbide-2-mononitrate (IS-2-MN) to the starting material isosorbide (IS) utilizing its alkaline environment, where NaOAc was also recovered effectively in the form of the trihydrate. For the solid waste, two different schemes were investigated: direct crystallization and catalytic hydrogenation. The former afforded useful isosorbide dinitrate (ISDN) efficiently, and the latter provided an efficient and scalable route to synthesize IS-5-MN from ISDN. The combinations of unit operations were evaluated on a 100 kg scale and proved to be feasible and robust. The waste recycling strategy provides an eco-friendly complement for the industrial-scale preparation of IS-5-MN, which minimizes waste emission during the process.