1605274-28-9

Basic information

• Product Name: 2-(4-((tert-butyl)phenyl)-2,2-difluoro-1-morpholinoethan-1-one)
• Synonyms: 2-(4-((tert-butyl)phenyl)-2,2-difluoro-1-morpholinoethan-1-one)
• CAS NO: 1605274-28-9
• Molecular Weight: 297.345
• Mol File: 1605274-28-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-((tert-butyl)phenyl)-2,2-difluoro-1-morpholinoethan-1-one)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-((tert-butyl)phenyl)-2,2-difluoro-1-morpholinoethan-1-one)(1605274-28-9)
• EPA Substance Registry System: 2-(4-((tert-butyl)phenyl)-2,2-difluoro-1-morpholinoethan-1-one)(1605274-28-9)

Safety Data

• Hazardous Substances Data: 1605274-28-9(Hazardous Substances Data)

Upstream product

• 121412-23-5 2-chloro-2,2-difluoro-1-morpholinoethan-1-one 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 149229-27-6 2-bromo-2,2-difluoro-1-morpholine-1-yl-ethanone 
• 3972-65-4 1-bromo-4-tert-butylbenzene 

Relevant articles and documents

Pd-catalyzed α-arylation of trimethylsilyl enolates of α,α-difluoroacetamides

We report the arylation and heteroarylation of α,α-difluoro-α-(trimethylsilyl)acetamides with aryl and heteroaryl bromides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)2Cy as ligand. A broad range of electronically varied aryl and heteroaryl bromides underwent this transformation to afford α-aryl-α,α-difluoroacetamides in high yields. Due to the electrophilicity of the fluorinated amide, this palladium-catalyzed cross-coupling reaction provides a versatile platform to generate a range of α,α-difluoro carbonyl compounds, such as α-aryl-α,α-difluoroketones, -acetaldehydes, -acetates, and acetic acids, and difluoroalkyl derivatives, such as 2-aryl-2,2-difluoroethanols and -ethylamines, under mild conditions.

Palladium-catalyzed difluoroalkylation of aryl boronic acids: A new method for the synthesis of aryldifluoromethylated phosphonates and carboxylic acid derivatives

The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed. This method provides a facile and useful access to a series of functionalized difluoromethylated arenes (ArCF2PO(OEt) 2, ArCF2CO2Et, and ArCF2CONR 1R2) that have important applications in drug discovery and development. Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway may be involved in the catalytic cycle. Palladium does it: The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed (see scheme). Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway may be involved in the catalytic cycle. Copyright