1607800-22-5

Basic information

• Product Name: C₂₇H₃₀ClNOS
• Synonyms: C₂₇H₃₀ClNOS
• CAS NO: 1607800-22-5
• Molecular Weight: 452.06
• Mol File: 1607800-22-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₀ClNOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₀ClNOS(1607800-22-5)
• EPA Substance Registry System: C₂₇H₃₀ClNOS(1607800-22-5)

Safety Data

• Hazardous Substances Data: 1607800-22-5(Hazardous Substances Data)

Upstream product

• 1607800-46-3 C₂₆H₂₈ClNOS 
• 74-88-4 methyl iodide 
• 1607800-19-0 C₂₆H₂₈ClNO₂ 
• 1607800-54-3 C₁₉H₂₃NO₂ 
• 31129-95-0 5-(3′-hydroxyphenyl)valeric acid 
• 1373132-90-1 methyl 5-(3-methoxyphenyl)pentanoate 
• 1616795-50-6 C₁₃H₁₆O₃ 
• 40138-66-7 3-(m-methoxyphenyl)propanal 
• 7252-82-6 3-(3-methoxyphenyl)propan-1-ol 
• 50704-52-4 methyl 3-(3-methoxyphenyl)propionate 
• 10516-71-9 3-(3-Methoxy-phenyl)-propionic acid 

Downstream Products

• 1607800-52-1 RE₁₆₅ 
• 1607800-25-8 C₄₇H₅₀ClNO₅Si 

Relevant articles and documents

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells

New derivatives of Vaccinia H1-related phosphatase (VHR) inhibitor RE12 (5) were designed by replacing the long straight alkyl chain with other hydrophobic functionalities containing two aromatic rings, with the aim of obtaining potent, cell-active inhibitors. We established a direct coupling reaction between tetronic acid derivative and thioimidate to prepare the RE derivatives 6a-6i efficiently. These compounds all showed VHR-inhibitory activity in the presence of 0.001% NP-40, whereas RE12 (5) was inactive under this condition, even at 100 μM. Further structure-activity studies focused on terminal substitution afforded trifluoromethyl derivative 6k (RE176) and nitro derivative 6l (RE177). The IC50 value of 6l in the presence of NP-40 was almost equivalent to that of RE12 (5) in its absence. Compound 6k (RE176) potently inhibited proliferation of HeLa cells.