1608997-57-4

Basic information

• Product Name: C₂₂H₁₂Cl₂I₂N₅O₄S^(1-)*Na⁽¹⁺⁾
• Synonyms: C₂₂H₁₂Cl₂I₂N₅O₄S^(1-)*Na⁽¹⁺⁾
• CAS NO: 1608997-57-4
• Molecular Weight: 790.139
• Mol File: 1608997-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₂Cl₂I₂N₅O₄S^(1-)*Na⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₂Cl₂I₂N₅O₄S^(1-)*Na⁽¹⁺⁾(1608997-57-4)
• EPA Substance Registry System: C₂₂H₁₂Cl₂I₂N₅O₄S^(1-)*Na⁽¹⁺⁾(1608997-57-4)

Safety Data

• Hazardous Substances Data: 1608997-57-4(Hazardous Substances Data)

Upstream product

• 87-02-5 7-amino-4-hydroxy-2-naphthalenesulfonic acid 
• 1608997-54-1 C₆H₃ClIN₂⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors

Vesicular Glutamate Transporters (VGLUTs) allow the loading of presynapic glutamate vesicles and thus play a critical role in glutamatergic synaptic transmission. VGLUTs have proved to be involved in several major neuropathologies and directly correlated to clinical dementia in Alzheimer and Parkinson's disease. Accordingly VGLUT represent a key biological target or biomarker for neuropathology treatment or diagnostic. Yet, despite the pivotal role of VGLUTs, their pharmacology appears quite limited. Known competitive inhibitors are restricted to some dyes as Trypan Blue (TB) and glutamate mimics. This lack of pharmacological tools has heavily hampered VGLUT investigations. Here we report a rapid access to small molecules that combine benefits of TB and dicarboxylic quinolines (DCQs). Their ability to block vesicular glutamate uptake was evaluated. Several compounds displayed low micromolar inhibitory potency when size related compounds are thirty to forty times less potent (i.e. DCQ). We then confirmed the VGLUT selectivity by measuring the effect of the series on vesicular monoamine transport and on metabotropic glutamate receptor activity. These inhibitors are synthesized in only two steps and count among the best pharmacological tools for VGLUTs studies.