1609032-02-1

Basic information

• Product Name: 3-(4-(tert-butyl)phenyl)-1-phenyl-1H-pyrazole
• Synonyms: 3-(4-(tert-butyl)phenyl)-1-phenyl-1H-pyrazole
• CAS NO: 1609032-02-1
• Molecular Weight: 276.381
• Mol File: 1609032-02-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-(tert-butyl)phenyl)-1-phenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(tert-butyl)phenyl)-1-phenyl-1H-pyrazole(1609032-02-1)
• EPA Substance Registry System: 3-(4-(tert-butyl)phenyl)-1-phenyl-1H-pyrazole(1609032-02-1)

Safety Data

• Hazardous Substances Data: 1609032-02-1(Hazardous Substances Data)

Upstream product

• 935-04-6 benzyl vinyl ether 
• 765-05-9 n-Decyl vinyl ether 
• 100-63-0 phenylhydrazine 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 75-20-7 calcium carbide 
• 591-50-4 iodobenzene 
• 115933-37-4 1-(4-tert-butylphenyl)-3-dimethylamino-prop-2-en-1-one 

Relevant articles and documents

Primary Vinyl Ethers as Acetylene Surrogate: A Flexible Tool for Deuterium-Labeled Pyrazole Synthesis

A novel synthetic path to 1,3-disubstituted pyrazoles and their deuterated derivatives was developed. It is based on the reaction of vinyl ethers with hydrazonoyl chlorides in the presence of triethylamine. The reaction mechanism, clarified by the joint experimental and computational study, involves 1,3-dipolar cycloaddition of the in situ generated nitrile imines to vinyl ethers and subsequent cleavage of alcohol from the formed alkoxypyrazoline. The results highlight the possibility of using vinyl ethers as acetylene surrogate and provide a novel access to pyrazoles, 4,5-dideuteropyrazoles and their regioselectively labeled derivatives, 5-deuteropyrazoles.

An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles

An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling.