1609078-46-7

Basic information

• Product Name: 3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile
• Synonyms: 3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile
• CAS NO: 1609078-46-7
• Molecular Weight: 281.401
• Mol File: 1609078-46-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile(1609078-46-7)
• EPA Substance Registry System: 3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile(1609078-46-7)

Safety Data

• Hazardous Substances Data: 1609078-46-7(Hazardous Substances Data)

Upstream product

• 1609078-45-6 N-[2-(1-benzylpiperidin-4-yl)ethyl]prop-2-yn-1-amine 
• 25895-60-7 sodium cyanoborohydride 
• 120014-32-6 (1-benzylpiperidin-4-yl)acetaldehyde 
• 78056-67-4 1-(phenylmethyl)-4-piperidineacetonitrile 
• 55022-82-7 2-(1-benzylpiperidin-4-ylidene)acetonitrile 
• 2450-71-7 Propargylamine 

Downstream Products

• 1609078-40-1 3-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)propanenitrile 

Relevant articles and documents

Multi-target-oriented protective agent neurocyte

PROBLEM TO BE SOLVED: To provide a promising multi target direction type pharmaceutical candidate molecule which is promising for treatments of Alzheimer-type dementia (AD), which is a molecule having good cell membrane permeability including blood brain barrier.SOLUTION: A compound designed by a conjunction method with which a benzylpiperidine part of an acetylcholine esterase (AChE) inhibitor, donepezil is connected through an oligomethylene linker and combined with a propargyl part having a monoamine oxidase(MAO) inhibition activity and 8-hydroxy-5-methylaminoquinoline functional group, i.e. a center nitrogen atom substituted by a pro-chelator motif of a biochemical metal, interacts with AChE and butyrylcholinesterase(BuChE), further MAOA and B.

Neuroprotective multi-target directed drugs

A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as with monoamino oxidase (MAO) A and B, has been synthesized. Novel compounds have been designed using a conjunctive approach that combines the benzylpiperidine moiety of the AChE inhibitor donepezil, connected through an oligomethylene linker, to a central nitrogen atom substituted with the propargyl moiety responsible for the MAO inhibition, and a 8-hydroxy-5-methylaminoquinoline functional group, the biometal pro-chelator motif. Overall, the results suggest that the new compounds are promising multitarget drug candidates with potencial impact for AD therapy.