1609541-66-3

Basic information

• Product Name: C₂₇H₂₉N₅S
• Synonyms: C₂₇H₂₉N₅S
• CAS NO: 1609541-66-3
• Molecular Weight: 455.627
• Mol File: 1609541-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₉N₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₉N₅S(1609541-66-3)
• EPA Substance Registry System: C₂₇H₂₉N₅S(1609541-66-3)

Safety Data

• Hazardous Substances Data: 1609541-66-3(Hazardous Substances Data)

Upstream product

• 132539-06-1 zyprexa 
• 155817-87-1 2-methyl-10-(4-methyl-piperazinyl)-4-prop-2-ynyl-4H-3-thia-4,9-diaza-benzo[f]azulene 
• 29289-13-2 2-iodo-4-methylaniline 

Relevant articles and documents

Synthesis of N-(3-arylprop-2-ynyl)substituted olanzapine derivatives as potential inhibitors of PDE4B

The linkage between dopamine D2 receptors and PDE activity via cAMP prompted us to design a series of novel N-(3-arylprop-2-ynyl)substituted olanzapine derivatives as potential inhibitors of PDE4B. The target compounds were conveniently prepared by using a simple and inexpensive method involving Pd/C-mediated CC bond forming reaction under Sonogashira conditions. A number of compounds were synthesized by using this strategy in good yields. Some of the compounds showed promising inhibition of PDE4B when tested in vitro that was supported by the docking studies.