16097-61-3

Basic information

• Product Name: 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine
• Synonyms: 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine;2-Amino-4-methoxy-6-(trifluoromethyl)pyrimidine;4-Methoxy-6-(trifluoroMethyl)pyriMidin-2-aMine;2-PyriMidinaMine,4-Methoxy-6-(trifluoroMethyl)-
• CAS NO: 16097-61-3
• Molecular Formula: C6H6F3N3O
• Molecular Weight: 193.12655
• Mol File: 16097-61-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 302.8 °C at 760 mmHg
• Flash Point: 136.9 °C
• Appearance: /
• Density: 1.423 g/cm³
• Vapor Pressure: 0.000967mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine(16097-61-3)
• EPA Substance Registry System: 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine(16097-61-3)

Safety Data

• Hazardous Substances Data: 16097-61-3(Hazardous Substances Data)

Usage

General Description

4-Methoxy-6-trifluoromethyl-2-pyrimidinamine is a chemical compound with the molecular formula C6H4F3N3O. It is a pyrimidine derivative with a methoxy group and a trifluoromethyl group attached to the 4th and 6th positions, respectively. 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its chemical properties make it useful in the development of new drugs and crop protection products. Additionally, it is utilized as a building block in the production of various organic compounds. Overall, 4-Methoxy-6-trifluoromethyl-2-pyrimidinamine has significant applications in the pharmaceutical and agricultural industries due to its versatile nature and potential as a key building block in compound synthesis.

InChI:InChI=1/C6H6F3N3O/c1-13-4-2-3(6(7,8)9)11-5(10)12-4/h2H,1H3,(H2,10,11,12)

Upstream product

• 124-41-4 sodium methylate 
• 16097-60-2 2-amino-4-chloro-6-(trifluoromethyl)pyrimidine 
• 1513-69-5 2-amino-4-hydroxy-6-(trifluoromethyl)pyrimidine 

Relevant articles and documents

New fluoro intermediates for herbicidal sulfonylureas

New pyrimidine and triazine intermediates for herbicidal sulfonylureas are prepared as follows: 2,4-dichloro-6-methylpyrimidine is converted via a halogenation, halogen exchange and substitution sequence to 2-amino-4-trifluoromethyl-6-trifluoromethoxypyrimidine. New fluoromethyl-triazines are available starting from guanidine, trichloroacetonitrile and difluoroacetic anhydride, or alternatively from thiocarbamoyl guanidine and chlorodifluoroacetic ester ring closure. To obtain new o-fluoroalkyl-benzenesulfonamide precursors, o-chlorobenzaldehyde was fluorinated with sulfur tetrafluoride, or a bromobenzene derivative was subjected to a substitution reaction with sodium pentafluoropropionate. Sulfonylureas derived from trifluoromethylpyrimidines with an m-methylthio substituent are selective post-emergence herbicides in cotton, presumably due to sulfone metabolization. Selectivity in wheat is obtained by combining 4-methoxy-6-trifluoromethyl-pyrimidine with a lipophilic difluoromethylbenzenesulfonamide moiety. Also in the difluoromethyl-triazine series, the combination with the difluoromethyl-benzenesulfonamide moiety is a good choice for wheat selectivity. Chlorodifluoromethyl- and trifluoromethyltriazines, however, combine better with an aromatic ester for best activity and selectivity in wheat. Selected compounds are undergoing broad field tests in wheat.