161095-64-3Relevant articles and documents
Synthesis of 7-Methyl-1,2-dihydroquinolin-2-ones as Angiotensin II Receptor Antagonists
Beier, Norbert,Labitzke, Erwin,Mederski, Werner W.K.R.,Radunz, Hans-Eckart,Rauschenbach-Ruess, Karin,Schneider, Bjoern
, p. 117 - 132 (2007/10/02)
A number of biphenyl substituted 1,2-dihydroquinolin-2-ones were synthesized by regiospecific alkylation of the corresponding 1H-derivatives.Again, these precursors were prepared in three steps by acetoacetylation of anilines, regiospecific C-alkylation of the resulting β-ketoanilides and subsequent condensation to the quinolines.One of the target compounds, 2--1,2-dihydroquinolin-3-yl>-N,N-dimethylacetamide (10e), is a potent angiotensin II receptor antagonist.