1612153-32-8

Basic information

• Product Name: (R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one
• Synonyms: (R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one;Ezetimibe Impurity O
• CAS NO: 1612153-32-8
• Molecular Formula: C20H20FNO4
• Molecular Weight: 357.3755032
• Mol File: 1612153-32-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 572.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.297±0.06 g/cm3(Predicted)
• PKA: 14.17±0.20(Predicted)
• CAS DataBase Reference: (R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one(1612153-32-8)
• EPA Substance Registry System: (R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one(1612153-32-8)

Safety Data

• Hazardous Substances Data: 1612153-32-8(Hazardous Substances Data)

Usage

Description

(R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one, also known as (4R)-4-Phenyl-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one, is a complex organic compound characterized by its unique molecular structure. It is an impurity compound associated with Ezetimibe, a pharmaceutical drug used for treating hyperlipidemia.

Uses

Used in Pharmaceutical Industry:
(R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one is used as an impurity compound in the production of Ezetimibe (E975000), which is an antihyperlipoproteinemic drug. As a cholesterol absorption inhibitor, Ezetimibe helps to lower the levels of bad cholesterol (LDL) in the blood, reducing the risk of cardiovascular diseases.
The presence of this compound as an impurity in Ezetimibe may have implications for the drug's efficacy, safety, and quality control. It is essential to monitor and control the levels of this impurity during the manufacturing process to ensure the drug meets the required standards for therapeutic use.