16126-32-2Relevant articles and documents
Synthesis of ecdysone. I. A novel synthesis of 2 beta,3 beta-dihydroxy steroids.
Mori,Shibata,Tsuneda,Sawai
, p. 460 - 465 (1967)
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Regioselective enzymatic acylation of vicinal diols of steroids
Silva, M. Manuel Cruz,Riva, Sergio,Sá E Melo, M. Luisa
, p. 3065 - 3073 (2007/10/03)
Monoacylated derivatives of a complete set of 2,3- and 3,4-vicinal diols of steroids were prepared by regioselective lipase-catalysed transesterification reactions. The enzymes displayed different selectivities towards the vicinal diols depending on the configuration of the hydroxyl groups.
AN ALTERNATIVE ROUTE TO 2α,3α-DIOLS FROM 2,3-UNSATURATED 5α-STEROIDS AVOIDING THE USE OF OSMIUM TETRAOXIDE
Cerny, Vaclav
, p. 2211 - 2217 (2007/10/02)
A method for preparation of 2α,3α-dihydroxy-5α-steroids from 2,3-unsaturated 5α-steroids without the use of OsO4 is described.It involves the sequence of epoxidation, cleavage of the oxirane ring by HI, acetylation, oxidative replacement of iodine by hydroxyl and alkaline hydrolysis (I-IV) without purification of the intermediates.The presence of a 6-keto group does not decrease the yields.The yields are comparable with those obtained by osmylation and the method can find general use, particularly in the synthesis of brassinolide analogs.