1612774-53-4

Basic information

• Product Name: (R)-tert-butyl 3-(3-amino-4-cyano-5-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
• Synonyms: (R)-tert-butyl 3-(3-amino-4-cyano-5-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
• CAS NO: 1612774-53-4
• Molecular Weight: 459.548
• Mol File: 1612774-53-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 3-(3-amino-4-cyano-5-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 3-(3-amino-4-cyano-5-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate(1612774-53-4)
• EPA Substance Registry System: (R)-tert-butyl 3-(3-amino-4-cyano-5-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate(1612774-53-4)

Safety Data

• Hazardous Substances Data: 1612774-53-4(Hazardous Substances Data)

Upstream product

• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 
• 330792-70-6 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 
• 1353993-49-3 tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate 
• 21218-94-0 methyl 4-phenoxybenzoate 
• 2215-77-2 4-Phenoxybenzoic acid 
• 1623-95-6 4-phenoxybenzoyl chloride 
• 330792-68-2 2-[hydroxy-(4-phenoxy-phenyl)-methylene]-malononitrile 
• 330792-69-3 2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile 
• 619-44-3 methyl 4-iodobenzoate 
• 108-95-2 phenol 

Downstream Products

• 1612774-54-5 (R)-tert-butyl 3-(3-amino-4-carbamoyl-5-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1612774-55-6 (R)-3-amino-5-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide 
• 1612774-15-8 (R)-1-(1-acryloylpiperidin-3-yl)-3-amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide 

Relevant articles and documents

INHIBITORS OF BRUTON'S TYROSINE KINASE

The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolites, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and is further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provided the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans. Formula (IV)