16147-07-2

Basic information

• Product Name: 1,3-Dimethoxy-5-nitrobenzene
• Synonyms: 1,3-Dimethoxy-5-nitrobenzene;3,5-Dimethoxy-1-nitrobenzene
• CAS NO: 16147-07-2
• Molecular Formula: C₈H₉NO₄
• Molecular Weight: 183.16136
• Mol File: 16147-07-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 89°C
• Boiling Point: 256.82°C (rough estimate)
• Appearance: /
• Density: 1.1693
• Refractive Index: 1.5310 (estimate)
• CAS DataBase Reference: 1,3-Dimethoxy-5-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethoxy-5-nitrobenzene(16147-07-2)
• EPA Substance Registry System: 1,3-Dimethoxy-5-nitrobenzene(16147-07-2)

Safety Data

• Hazardous Substances Data: 16147-07-2(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Subclass

Nitrobenzene derivative

Functional groups

Two methoxy groups and one nitro group

Structure

Attached to a benzene ring

Applications

Synthesis of pharmaceuticals and agrochemicals, organic reactions as a reagent

Physical state

Yellow crystalline solid

Odor

Slightly sweet

Health hazards

Potential irritant to skin, eyes, and respiratory system

Environmental risks

May pose risks and should be handled and disposed of carefully to prevent adverse effects on human health and the environment

Upstream product

• 7087-60-7 1-fluoro-3-methoxy-5-nitrobenzene 
• 124-41-4 sodium methylate 
• 10272-07-8 3.5-dimethoxyaniline 
• 1203549-54-5 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 60319-09-7 3,5-dimethoxyphenyl trifluoromethanesulfonate 
• 408315-24-2 1,3-diacetoxy-5-nitro-benzene 
• 4969-30-6 (+/-)-1-nitro-1-deoxy-myo-inositol 
• 4969-30-6 muco-nitrocyclitol 
• 77-78-1 dimethyl sulfate 
• 151-10-0 1,3-Dimethoxybenzene 
• 20734-70-7 5-nitroresorcinol 
• 67-56-1 methanol 

Downstream Products

• 861548-13-2 1,5-dimethoxy-2,3-dinitro-benzene 
• 861526-20-7 1,5-dimethoxy-2,3,4-trinitro-benzene 
• 10272-07-8 3.5-dimethoxyaniline 
• 104968-58-3 1-isothiocyanato-3,5-dimethoxybenzene 
• 20734-70-7 5-nitroresorcinol 
• 18523-15-4 1,3,5-trimethoxy-2,4-dinitro-benzene 

Relevant articles and documents

Synthesis and initial biological evaluation of myxocoumarin B

The myxocoumarins A and B from Stigmatella aurantiaca MYX-030 are natural products featuring unusual nitro- and long-chain alkyl substitution. While myxocoumarin A was shown to exhibit strong antifungal properties, the antifungal potential of myxocoumarin

Nucleophilic Nitration of Arynes by Sodium Nitrite and its Multicomponent Reaction Leading to Double-Functionalized Arenes

An unusual nucleophilic nitration of arynes by NaNO2 in the presence of water has been developed, and the concept was further demonstrated to accomplish a double functionalization of arynes using a multicomponent reaction protocol to synthesize pharmaceutically important (2-nitrophenyl)methanol derivatives. Such substitution ortho to -NO2 is difficult by other means. The reaction conditions are mild and avoid the use of strong acids, expensive transition metal catalysts, and additives.

LIGANDS FOR TRANSITION-METAL-CATALYZED CROSS-COUPLINGS, AND METHODS OF USE THEREOF

Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition-metal-catalyzed cross-coupling reactions.